Biophoretic Therapeutic Systems, LLC

Nitric Biotherapeutics, Inc.

Transport Pharmaceuticals Inc.

The Uab Research Foundation

Geltex Pharmaceuticals, Inc.

Lipimetix Development, LLC

Dennis I Goldberg

Julian L Henley

Kuo Wei Chang

Joseph Potter

Christopher H Porter

V Lorenzo Porcelli

James D Derouin

Stephen Randall Holmes-Farley

W Harry Mandeville, Iii

John S Petersen

Gattadahalli M Anantharamaiah

Robert W Etheredge, Iii

James Kelland

Steven K Burke

Paul K Rand

Anthony Patrick Charles Jones

Disclosed are synthetic apolipoprotein E-mimicking peptides, derivatives thereof, and related peptides, which are useful as therapeutic agents for reducing plasma cholesterol; synthetic methods of making the peptides; pharmaceutical compositions comprising the peptides, and methods of treating lipid and metabolic disorders using the disclosed synthetic apolipoprotein E-mimicking peptides and compositions thereof. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

ApoE mimetic peptides and higher potency to clear plasma cholesterol

An electrokinetic delivery system for personal use in self-administration of a medicament to a treatment site on an individual includes a device shaped to conform with the shape of a portion of an individual's finger from a tip thereof to a location past the first finger joint. A self-contained power source is carried by the device and a first electrode is carried by the device adjacent a distal end portion thereof and the tip of the individual's finger. The first electrode is in electrical contact with the power source. A second electrode is carried by the device for contact with the individual's finger. The second electrode is in electrical contact with the power source. Upon application of the first electrode over a treatment site with the medicament disposed between the first electrode and the treatment site and completion of an electrical circuit through the individual's body and said electrode, the device applies current for electrokinetically driving the medicament into the treatment site.

Electrokinetic delivery system for self-administration of medicaments and methods therefor

A method for delivering a substance to an infected nail of an individual is described. The method includes the step of applying a device to at least one infected nail of an individual, where the device includes at least one active electrode and at least one counter electrode, where the at least one counter electrode is in contact with the individual, and where the device is connected to at least one power source. The method also includes the steps of disposing a medicament between the at least one active electrode and the at least one infected nail, applying a salt solution to the at least one infected nail, and providing an electrical current from the power source to the at least one active electrode to facilitate delivery of the medicament into the region of the at least one infected nail.

Methods and systems for electrokinetic delivery of a substance

A device for electrokinetic delivery of medicament to a treatment site includes a cartridge having an active electrode and a membrane overlying the active electrode and a medicament or a medicament and an electrically conductive carrier therefor, carried by the membrane in electrical contact with the electrode. The electrode opens through a surface of the cartridge remote from the membrane for connection with an electrical connector carried by the device. An locking element releasably couples the cartridge to the housing.

Combination cartridge and device for electrokinetic delivery of medicament to a treatment site

A system for delivering a substance into a body at a treatment site that includes an alternating current source and a plurality of electrodes. Circuitry is connected between the alternating current source and the electrodes for supplying current to the electrodes when the electrodes are in electrical contact with said body so that a uni-directional current flow for delivering the substance into the body is maintained at the treatment site and a bi-directional current flow is maintained throughout the body. At least one of the electrodes is divided into sub-electrodes to, for example, reduce hazards associated with current concentration. These and other systems and methods are adaptable for large treatment areas and/or use a convenient and low-cost arrangement of electronics.

Systems and methods for electrokinetic delivery of a substance

An electrokinetic delivery or diagnostic device for personal use and self-administration of a medicament to a treatment site is provided. The device includes a housing containing a power supply, a first active electrode and a ground tactile electrode. An applicator includes a pad for containing medicament for overlying the first electrode of the device. The medicament may be applied by the user to the pad, contained within the pad or contained in rupturable capsules within the pad, together with a hydrogel if necessary for imparting electrical conductivity whereby, upon application of the applicator to the treatment site, the medicament is electrokinetically transported into the treatment site. In another form, the applicator is self-contained, having a power supply, a first electrode overlying a pad and a ground electrode from the opposite side from the pad whereby the individual presses the pad against the treatment site to complete the electrical circuit and electrokinetically drive the medicament into the treatment site.

Electrokinetic delivery of medicaments

Finger-mounted electrokinetic delivery system for self-administration of medicaments and methods therefor

Method for treating hypercholesterolemia with polyallylamine polymers

Growing community of inventors

South Brookline, MA, United States of America

Dennis I Goldberg