The Procter Gamble Company

The Proctor 'gamble Company

Procter & Gamble Pharmaceuticals, Inc.

Dennis G Nelson

Marion David Francis

Frank Hallock Ebetino

John M Janusz

Susan Mary Kaas

Carl Edward Catrenich

The present invention relates to quaternary nitrogen-containing phosphate compounds, and the pharmaceutically-acceptable salts and esters thereof having the general structure: ##STR1## wherein: Z is a saturated, unsaturated, or aromatic, monocyclic or polycyclic carbocycle or monocyclic or polycyclic heterocycle containing one or more heteroatoms selected from O, S, or N;

Quaternary nitrogen-containing phosphonate compounds, pharmaceutical

The subject invention encompasses methods and compositions comprising phosphate derivatives of triclosan for treating or preventing dental plaque, gingivitis or periodontal disease, of the oral cavity in humans or lower animals.

Oral care compositions comprising certain substituted diphenyl ethers

Methods for the treatment of a human or lower animal subject having an H. pylori-mediated upper gastrointestinal disorder comprising administering to said subject a safe and effective amount of a diphenyl ether phosphate ester of the following formula: ##STR1## wherein n is an integer from 0 to 3, or a pharmaceutically-acceptable salt thereof.

Methods and compositions of diphenyl ether phosphate esters for the

The present invention relates to quaternary nitrogen-containing phosphonate compounds, and the pharmaceutically-acceptable salts and esters thereof and having the general structure: ##STR1## wherein R.sup.1, R.sup.2, R.sup.5 and R.sup.8 are defined in claim 1, m and n are integers from 0 to 10; m+n is from 0 to 10;

Growing community of inventors

West Chester, OH, United States of America

Dennis G Nelson