University of Colorado

Sirna Therapeutics, Inc.

Dennis G Macejak

Robert L Garcea

Leonid Beigelman

James A McSwiggen

Chandra Vargeese

Nassim Usman

Weimin Wang

James D Thompson

Shawn Patrick Zinnen

Peter Haeberli

Tongqian Chen

Pamela Pavco

Kathy L Fosnaugh

David Morrissey

Bharat Chowrira

Narendra K Vaish

Sharon F Jamison

Embodiments of the present invention provide compositions and methods for recombinantly generating tagless constructs of proteins or peptides. In certain embodiments, recombinant proteins or peptides disclosed herein concern human papilloma virus (HPV). Other embodiments concern using these constructs in compositions to elicit immune responses in a subject to one or more HPV types. Therapeutic and prophylactic vaccines for the prevention and treatment of viral infections are also disclosed. Nucleic acids and expression vectors coding for constructs contemplated herein are provided. In certain embodiments, an HPV capsid protein generated is devoid of any fusion tags. In addition, truncated forms of HPV L1 are contemplated.

Compositions, methods and uses for improved human papilloma virus constructs

The present invention concerns methods and reagents useful in modulating gene expression in a variety of applications, including use in therapeutic, diagnostic, target validation, and genomic discovery applications. Specifically, the invention relates to synthetic chemically modified small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules capable of mediating RNA interference (RNAi) against target nucleic acid sequences. The small nucleic acid molecules are useful in the treatment of any disease or condition that responds to modulation of gene expression or activity in a cell, tissue, or organism.

RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)

Growing community of inventors

Arvada, CO, United States of America

Dennis G Macejak