University of Toronto

Kane Biotech Inc.

Dennis G Cvitkovitch

Srinivasa Madhyastha

Yi-Chen Cathy Huang

Celine Levesque

Compounds that competitively inhibit binding of CSP tohistidine kinase are provided. The compounds are preferably a peptide or an antibody, and are preferably a derivative of [SEQ ID NO:2], a fragment of [SEQ ID NO:2] or a derivative of a fragment of [SEQ ID NO:2]. Methods of making these compounds and their use for inhibiting the growth of, for inhibiting dental caries, and for improving dental health are also disclosed.

Signal peptides, nucleic acid molecules and methods for treatment of caries

Peptide analogues ofCSP peptide which inhibit biofilm formation, uses thereof in the preparation of pharmaceutical compositions, antimicrobial compositions and uses thereof in the treatment and prevention of infections caused by biofilm forming bacteria, dental plaque formation, and conditions caused by dental plaque associated bacteria are provided.

Growing community of inventors

Oakville, Canada

Dennis G Cvitkovitch