3m Innovative Properties Company

3m Innovative Properties

Kindeva Drug Delivery, L.p.

Dennis G Berry

Ryan Patrick Simmers

Paul A Martinson

Chin-Yee Ng

An article comprising at least one microneedle is provided. The article can comprises a first side and a second side opposite the first side. The first side comprises a central cavity portion and a platform portion, with at least one microneedle extending therefrom, wherein the platform portion is not coplanar with the central cavity portion. The platform portion substantially surrounds the central cavity portion. The at least one microneedle comprises a body comprising an outer surface; a base segment having a base and a first shape; a tip segment having a tip and a second shape, wherein the second shape is distinct from the first shape; a transition plane that delineates the base segment and the tip segment; and a central axis. Methods of using the article are also provided.

Article comprising a microneedle and methods of use

An article having at least one microneedle () is provided. The microneedle includes a base (), an elongated body () having a central axis () and a body diameter (), a tip portion (), and a hollow channel (). The a tip portion includes a tip (), a first bevel face () oriented diagonally with respect to the central axis and extending through at least 75% of the body diameter, a second bevel face () oriented substantially perpendicular to the central axis and intersecting the first bevel face, and a bevel opening defined by a first edge () of the first bevel face and a second edge () of the second bevel face. The hollow channel extends axially into the body from the bevel opening ().

Hollow microneedle with beveled tip

An articlecomprising at least one microneedleis provided. The article comprises a first sideand a second sideopposite the first side. The first side comprises a central cavity portionand a platform portion, with at least one microneedle extending therefrom, wherein the platform portion is not coplanar with the central cavity portion. The platform portion substantially surrounds the central cavity portion. The at least one microneedlecomprises a body comprising an outer surface; a base segmenthaving a base and a first shape; a tip segmenthaving a tipand a second shape, wherein the second shape is distinct from the first shape; a transition planethat delineates the base segment and the tip segment; and a central axis.

Article comprising a microneedle

An articlehaving a first sidethat has a central portiondefined by a first edge, a microneedle-free peripheral portionthat substantially surrounds the central portion, and a plurality of spaced-apart hollow microneedles. Each microneedle has a body that includes an outer surface; a base segmenthaving a baseand a first shape; a tip segmenthaving a tipand a second shape, wherein the second shape is distinct from the first shape; a transition planethat delineates the base segment and the tip segment; and a central axis. An angle, defined by an intersection of the central axis of at least one microneedle and a shortest line extending from the first edge and through the transition plane of the at least one microneedle, is less than about 50&#xb0;.

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Maplewood, MN, United States of America

Dennis G Berry