Allergan, Inc.

Allergan Industrie, Sas

Dennis E Van Epps

Wha Bin Im

Guang-Liang Jiang

Thomas E Powell

David J Schuessler

Gregory H Altman

Jingsong Chen

Wha-Bin Im

Alexei Goraltchouk

Rebecca L Horan

Adam L Collette

Jordan M Thompson

Pierre F Lebreton

Xiaojie Yu

Jacob Pollock

Cecile Gousse

Lauren Elizabeth Kokai

Cunqi Cui

Nicholas J Manesis

Futian Liu

Nicolas Prost

Sumit Paliwal

Darin J Messina

Robert L Nieto

Barbara Nofrey

Claudia Renteria

Phat Ngo

Kevin Ma

Guan-Liang Jiang

Cindy D Ren

Miram M Abiad

Iossif A Strehin

Thomas Powell

Rebeca L Horan

Jing Song Chen

Hydrogels comprising a macromolecular matrix and water may be used to augment soft tissue of a human being, promote or support cell or tissue viability or proliferation, create space in tissue, and for other purposes. A macromolecular matrix may comprise a hyaluronic acid component crosslinked to a collagen component.

Crosslinked hyaluronic acid-collagen gels for improving tissue graft viability and soft tissue augmentation

Disclosed herein are polyurethane polymer matrices with a porosity of from about 20 microns to about 90 microns that are useful in promoting closure and protection of incision sites; supporting the lower pole position of breast implants; and providing a partial or complete covering of breast implants to provide a beneficial interface with host tissue and to reduce the potential for malpositioning or capsular contracture. The disclosed matrices can be seeded with mammalian cells.

Bioerodible matrix for tissue involvement

Devices and methods are provided for making a variable textured breast implant when used in conjunction with a breast implant mandrel having a molding surface and a stem depending therefrom.

Device and method for making a variable surface breast implant

A soft breast prosthesis is provided, the prosthesis having a surface configuration advantageous for dual plane placement of the prosthesis in a breast.

Dual plane breast implant

A soft prosthetic implant shell, such as a silicone breast implant shell, that has discrete fixation surfaces thereon for tissue adhesion. The fixation surfaces may be provided on the posterior face of the shell, as well as either on the periphery or at discrete areas on the anterior face. Band-shaped fixation surfaces may be provided on the anterior face of the shell to generally match the angle of pectoralis major or pectoralis minor muscle groups. The fixation surfaces may be roughened areas of the shell, or may be separate elements adhered to the shell.

Soft filled prosthesis shell with discrete fixation surfaces

Dermal filler hydrogel compositions, methods of making them, and methods of using them to treat soft tissue conditions, such as wrinkles, are provided. The compositions contain a crosslinked hyaluronic acid-based polymer and one or more additional ingredients, and are stable to sterilization by heat and/or pressure treatment. The additional ingredients include vasoconstrictive agents, antioxidant agents, such as a ascorbic acid agents, and/or anesthetic agents.

Stable hydrogel compositions including additives

A soft prosthetic implant, such as a silicone breast implant, is provided. The implant has a variety of different surfaces, for example, different textures, located on different areas of the outer surface of the implant.

Soft filled prosthesis shell with variable texture

Methods for breast reconstruction and augmentation are provided which may reduce the incidence of capsular contracture. Methods for treating an encapsulated breast and reducing potential for capsular contracture in the breast are also provided.

Surgical methods for breast reconstruction or augmentation

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Goleta, CA, United States of America

Dennis E Van Epps