Vanderbilt University

Washington University

Dana-farber-cancer Institute Inc.

Arch Development Corporation

The University of Chicago

Other

Icos Corporation

Dennis E Hallahan

Donald W Kufe

Bernard Roizman

Ralph R Weichselbaum

Vikas P Sukhatme

Shimian Qu

Zhaozhong Han

Raymond Mernaugh

Heping Yan

Chanchal Sadhu

Joel S Hayflick

Eugenia M Yazlovitskaya

Christopher D Willey

Vaishali Kapoor

Ralph H Weichselbaum

Gregory S Sibley

The disclosure provides antigen binding proteins useful in the recognition of tumor cells and tumor specific delivery of drugs and therapies.

Antibodies to TIP1 and methods of use thereof

The present invention is directed towards the compositions of peptide constructs that bind to GRP78 and the methods of use thereof.

Compositions targeting radiation-induced molecules and methods of use thereof

The present invention is directed towards isolated antibodies that bind to GRP78.

Antibodies to GRP78

A method for identifying a molecule that binds an irradiated tumor in a subject and molecules identified thereby. In some embodiments, the method includes the steps of (a) exposing a tumor to ionizing radiation; (b) administering to a subject a library of diverse molecules; and (c) isolating from the tumor one or more molecules of the library of diverse molecules, whereby a molecule that binds an irradiated tumor is identified. Also provided are targeting ligands that bind an irradiated tumor and therapeutic and diagnostic methods that employ the disclosed targeting ligands.

Ligands to radiation-induced molecules

The present invention provides isolated antibodies that bind to 14-3-3 epsilon that are useful in the recognition of tumor cells and tumor specific delivery of drugs and therapies.

Monoclonal antibodies to human 14-3-3 epsilon and human 14-3-3 epsilon sv

The present invention is directed towards isolated antibodies that bind to GRP78 and TIP-1.

Antibodies to TIP-1

A method for identifying a molecule that binds an irradiated tumor in a subject and molecules identified thereby. The method includes the steps of: (a) exposing a tumor to ionizing radiation; (b) administering to a subject a library of diverse molecules; and (c) isolating from the tumor one or more molecules of the library of diverse molecules, whereby a molecule that binds an irradiated tumor is identified. Also provided are therapeutic and diagnostic methods using targeting ligands that bind an irradiated tumor.

Phage antibodies to radiation-inducible neoantigens

The presently disclosed subject matter relates generally to the fields of molecular biology and medicine. More particularly, it concerns methods involving the use of GSK3 inhibitors in combination with radiation therapies. In some embodiments, administration of a GSK3 inhibitor to a subject results in an amelioration of cognitive decline, toxicity to vascular endothelial cells, and/or neuron death associated with radiation therapy alone.

Use of GSK3 inhibitors in combination with radiation therapies

A method for increasing the radiosensitivity of a target tissue in a subject is disclosed. In some embodiments, the methods includes administering a cytosolic phospholipase A2 (cPLA) antagonist to the subject, whereby the radiosensitivity of the target tissue is increased. Also disclosed are methods for suppressing tumor growth in a subject and methods for inhibiting tumor blood vessel growth.

[object Object]

Provided are methods for modulating the proliferation of cells and tissues. In some embodiments, the methods include administering to a subject an effective amount of a modulator of a biological activity of a bone marrow X kinase (Bmx) gene product. Also provided are methods for increasing the radiosensitivity of a target cell or tissue, methods for suppressing tumor growth, methods for inhibiting tumor blood vessel growth, and compositions that include modulators of a biological activity of a bone marrow X kinase (Bmx) gene product.

Growing community of inventors

Nashville, TN, United States of America

Dennis E Hallahan