Yale University

Itn Energy Systems, Inc.

Other

International Business Machines Corporation

The University of North Carolina at Charlotte

Dennis D Spencer

Hitten P Zaveri

Bruce Lanning

Gregory J Nuebel

James A Nolan

Bharat S Joshi

Hariklia Deligianni

Roy Rongqing Yu

Emily R Kinser

Mark T Reed

David A Putz

Mohan S Misra

David M Binkley

Themis Kyriakides

Jason Gerrard

The present invention provides devices comprising multimodal depth electrodes for real-time quantification of chemistry and electrophysiology of the body. The devices are useful in several applications, including monitoring primary and secondary brain injury. The multimodal depth electrodes electrically transduce signals from biological parameters of interest, including EEG, temperature, pressure, oxygen level, blood flow, and chemistry.

Multiplexed implantable sensor probe

A structure for monitoring and stimulation includes an external power supply unit. The structure also includes an internal hub communicatively coupled to the external power supply unit. The structure further includes a plurality of sensor modules communicatively coupled to the internal hub by a plurality of flexible interconnects. The plurality of sensor modules include three-dimensional (3D) comb sensor devices.

Three-dimensional silicon-based comb probe with optimized biocompatible dimensions for neural sensing and stimulation

A clinical grid electrode system for seizure control through local cooling, mapping brain function and me provision of reversible functional ablation. The system includes a modular, scalable, cooling and sensing array composed of a plurality of cooling sensing elements. The system also includes a control system to which die cooling and sensing array is coupled for providing for control and monitoring of die cooling sensing elements making up the cooling and sensing array.

Brain cooling system

A wireless system for brain monitoring/mapping of neurological-disorder patients includes a plurality of electrodes each configured for surface abutment of brain tissue and main circuitry for placement outside a body of a patient and configured to transmit power at radio frequencies and send and receive data using infrared energy. Remote circuitry is provided for subcutaneous implantation in a head of the patient. The remote circuitry is connected to the plurality of electrodes and includes a multiplexer sampling signals from the plurality of electrodes. The multiplexer outputs electrode signals to an amplifier and A/D converter for transmission to the main circuitry. The remote circuitry is configured to (a) receive transmitted power at radio frequencies from the main circuitry, (b) capture and digitize full-bandwidth EEG signals from each of the electrodes, and (c) send data to and receive data from the main circuitry using infrared energy.

Wireless system for epilepsy monitoring and measurement

A wireless system for monitoring a patient's brain tissue including (1) a plurality of electrodes abutting brain tissue, (2) main circuitry outside the patient's body to transmit power at radio frequencies and send/receive data using infrared energy, and (3) subcutaneously-implanted remote circuitry connected to the electrodes and configured to (a) receive transmitted RF power, (b) capture and digitize EEG signals from the electrodes, and (c) send/receive data to/from the main circuitry using IR energy, including sending digitized EEG signals from each electrode to capture the full bandwidth of each EEG signal. The system preferably includes circuitry to measure the electrical impedance of each electrode for real-time monitoring of the condition of the electrode/tissue interfaces to enhance interpretation of captured EEG signals.

Growing community of inventors

Woodbridge, CT, United States of America

Dennis D Spencer