Synthelabo

Pierre Fabre Medicament

Dennis C Bigg

Mireille Sevrin

Claude C Morel

Jean-Francois Patoiseau

Pascal George

Jean-Marie Autin

Jacques Menin

Jean-Pierre Rieu

Alain Duflos

Robert Kiss

Jean-Pierre Merly

Jean-Pierre Tarayre

Henri Cousse

Gilbert Mouzin

Jean-Claude Jacquesy

Daniel C Obitz

Salomon Z Langer

Christian J Warolin

Bernard Bonnaud

Anna Kruczynski

Marie-Paule Jouannetaud

Jacques Fahy

Michel Peynot

Guy Pitet

Michel Mangane

Fabien Zunino

Christian Faure

Corinne Veronique

Francoise Couret

Jean-Louis Vidaluc

Roland Schneider

Patrick Lesimple

Christian Berrier

1,2-dihydro-2-oxo-3-aminoquinoxaline derivatives, their preparation and

Antimitotic binary alkaloid derivatives from catharanthus roseus

Sulfonamides derived from benzocyclic or benzoheterocyclic acids, their

The invention relates to novel substituted 3-piperazinylalkyl-2,3-dihydro-4H-1,3-benzoxazin-4-ones of formula I ##STR1## their pharmaceutically acceptable inorganic or organic salts, optionally in their hydrated form, the racemates, the enantismers or their mixtures, their preparation and their use as medicaments as well as all the pharmaceutical compositions of I which are or are not combined with another active principle.

Substituted 3-piperazinylalkyl-2,3-dihydro-4H-1,3-benzoxazin-4-ones and

New urea derivatives corresponding to the general formula 1 ##STR1## in which: R.sup.1 represents a C.sub.1 -C.sub.4 alkyl group;

New urea derivatives, their preparation and their application in therapy

The application discloses pharmacologically-active derivatives of 4-aminomethyl piperidine having the general formula 1 ##STR1## wherein the symbols have the meanings set forth in the Specification, as well as pharmaceutically-acceptable acid addition salts thereof, the use of the compounds as serotoninergic receptor ligands and for the treatment of anxiety, depression, and other related serotoninergic system disorders, pharmaceutical compositions thereof, and a method for their preparation.

Derivatives of 4-aminomethylpiperidine, their preparation and their use

The application discloses pharmacologically-active 3-hydroxy-1-phenyl-1,4-dihydro-4-oxopyridazine compounds, derivatives thereof, a method for the preparation thereof, pharmaceutical compositions thereof, and a method of treating anxiety and other physiological abnormalities therewith.

3-hydroxy-substituted-1-phenyl-1,4-dihydro-4-oxopyridazines and

Derivatives of 1,2-dihydro 2-oxo quinoxalines, their preparation and

[(1-Arylpyrrolidin-2-yl)methyl]piperazine compounds corresponding to the formula ##STR1## in which Z denotes a group of formula N-R.sub.1 in which R.sub.1 is either a hydrogen atom or a C.sub.1-3 alkyl group or a group of formula Ar--C.sub.n H.sub.2n in which n denotes 0, 1 or 2 and Ar denotes a phenyl group optionally substituted by one or more halogen atoms and/or C.sub.1-3 alkyl or C.sub.1-3 alkoxy radicals, or a group of formula COR.sub.2 in which R.sub.2 denotes the CH.sub.3, C.sub.6 H.sub.5, CH.sub.2 C.sub.6 H.sub.5 or OC.sub.2 H.sub.5 group and their salts of addition to pharmaceutically acceptable acids. The compounds are useful for the treatment of neurological disorders.

[(1-arylpyrrolidin-2-yl)methyl]piperazine derivatives, their preparation

The present invention relates to compounds of the Formula I: ##STR1## wherein R is hydrogen, alkyl, cycloalkyl, phenyl, or alkylphenyl, and n is 2 through 4, the production thereof, pharmaceutical compositions thereof, and their use in antineoplastic therapy.

Spirocyclic N, O derivatives of cyclotriphosphazenes and their use in

A benzazepine derivative which is a compound of formula (I): ##STR1## in which each of m and n denotes the number 1, or

2,3-dihydro-1H-isoindole derivatives and their application in therapy

The present invention relates to derivatives of 1-phenyl 1,4-dihydro 3-amino 4-oxo pyridazines of the general formula I: ##STR1## and the production thereof. It also concerns pharmaceutical compositions comprising as active principle a compound of general formula I and use thereof for treatment of central nervous system disturbances, especially as an anxiolytic.

Derivatives of 1-phenyl 1,4-dihydro 3-amino 4-oxo pyridazines, their

A method of preparing 1-phenyl-1-diethylaminocarbonyl-2-phthalimidomethyl-cyclopropane-Z and key intermediates therefor are disclosed. This method is characterized by the following successive steps:

Method of preparing

A compound which is a pyrido[3,4-b]derivative of formula (I) ##STR1## in which R is a hydrogen atom or an alkyl carbonyl, arylalkylcarbonyl or arylcarbonyl group of formula COR.sub.1 wherein R.sub.1 is a C.sub.1 -C.sub.6 alkyl group, a benzyl group or a phenyl group unsubstituted or substituted with 1 to 3 substituents chosen from halogen atoms and trifluoromethyl, C.sub.1 -C.sub.3 alkyl and C.sub.1 -C.sub.3 alkoxy groups or R is an alkoxycarbonyl or benzyloxycarbonyl group of formula COOR.sub.2 wherein R.sub.2 is a C.sub.1 -C.sub.6 alkyl group or a benzyl group, or R is a substituted aminocarbonyl group of formula CONHR.sub.3 wherein R.sub.3 is a C.sub.1 -C.sub.6 alkyl group or a phenyl group, or R is an arylsulphonyl group of formula SO.sub.2 R.sub.4 wherein R.sub.4 is a phenyl group, or a pharmacologically acceptable acid addition salt thereof useful for treating hypertension, depressive state or anxiety state.

2-[(4-piperidyl)methyl]-1,2,3,4-tetrahydro-9H-pyrido[3,4-b]indole

2-(4,5-Dihydro-1H-imidazol-2-yl)-1,2,4,5-tetrahydropyrrolo[3,2,1-hi]indole derivatives and their pharmaceutically acceptable salts are useful an antidiabetic agents.

2-(4,5-dihydro-1H-imidazol-2-yl)-1,2,4,5-tetrahydropyrrolo[3,2,1

Growing community of inventors

Castres, France

Dennis C Bigg