Umc Utrecht Holding B.v.

Albert-Ludwigs-Universitat Freiburg

Gadeta B.v.

Dennis Beringer

Jürgen Herbert Ernst Kuball

Jose Alberto Villacorta Hidalgo

Anke Janssen

Paul Fisch

Anna Vyborova

Zsolt Sebestyen

The present invention relates to a method for identifying δT-cell (or γT-cell) receptors chains or parts thereof that mediate an anti-tumor or anti-infection response by identifying amino acid sequences comprising δT-cells (or γT-cell) receptors chains or parts thereof that are shared between different donors.

Method of cell therapy

The current disclosure provides polypeptide constructs and cells comprising CDR3 regions of γ9. δ2 or both, that selectively bind a J-configuration of CD277 on a target cell. The disclosure also provides pharmaceutical compositions with the disclosed polypeptides or cells and methods of using these compositions in the treatment of cancer.

Compositions and methods for cell targeting therapies

The present invention relates to a method for identifying &#x3b4;T-cell (or &#x3b3;T-cell) receptors chains or parts thereof that mediate an anti-tumor or anti-infection response by identifying amino acid sequences comprising &#x3b4;T-cells (or &#x3b3;T-cell) receptors chains or parts thereof that are shared between different donors.

Method for identifying &#x3b4;T-cell (or &#x3b3;T-cell) receptor chains or parts thereof that mediate an anti-tumour or an anti-infective response

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Utrecht, Netherlands

Dennis Beringer