Sartorius Stedim Biotech Gmbh

Denise Van Rossum

Dieter Melzner

Susanne Drebing

Thomas Scheper

Johanna-Gabriela Walter

Alfons Kesting

Carsten Zeilinger

Eric Jallérat

Thomas Schueler

Frank Stahl

The present invention relates to a multiparameter lateral flow strip (), comprising a microporous membrane layer () supported on a liquid-impermeable support layer (), for lateral flow of a liquid through the microporous membrane layer (), wherein the microporous membrane layer () has two or more flow lanes () in the direction of lateral flow, wherein said two or more flow lanes () are separated by hydrophobic separation channels (), and wherein each of said two or more flow lanes () comprises a detection spot () including a binding agent, wherein said two or more flow lanes () are isomorphic lanes. Furthermore, the present invention relates to a multiparameter lateral flow immunoassay device comprising said multiparameter lateral flow membrane (), the use of said multiparameter configured lateral flow membrane () in an immunological test, as well as to a method for the manufacture of said multiparameter configured lateral flow membrane ().

Lateral flow membrane designed for multiparameter readouts and compact multiparameter lateral flow immunoassay device comprising the same

The present invention relates to a patterned membrane structure comprising a microporous membrane layer, wherein the microporous membrane layer includes a plurality of flow lanes, the flow lanes are separated by hydrophobic separation channels, and the flow lanes and hydrophobic separation channels form a repetitive pattern; and a method for manufacture of the patterned membrane structure. The patterned membrane structure according to the present invention represents an industrial scale precursor of membranes such as a multiparameter lateral flow membrane comprising separated flow lanes.

Patterned membrane structure

The present invention relates to a lateral flow membrane arrangement (), comprising a microporous membrane layer () and a liquid-impermeable support layer (), for lateral flow of a liquid through the microporous membrane layer (), wherein the microporous membrane layer () is supported on the liquid-impermeable support layer () and has at least one detection zone () and at least one non-detection zone, wherein binding agents are immobilized in the at least one detection zone (), the liquid-impermeable support layer () has at least one zone having a large thickness and at least one zone having a small thickness, the microporous membrane layer () is supported on the liquid-impermeable support layer () such that said at least one detection zone is provided above said at least one zone of the support layer having a large thickness and said at least one non-detection zone is provided above said at least one zone of the support layer having a small thickness, the zones are oriented in a direction orthogonally to the lateral flow direction (a) of said liquid, the detection zone () has a thickness () of 100 to 150 &#x3bc;m over the entire width of the membrane, the non-detection zone has a thickness () of at most 300 &#x3bc;m over the entire width of the membrane, and the lateral flow membrane arrangement () has a constant thickness (), as well as to a lateral flow immunoassay device comprising said membrane arrangement ().

Lateral flow membrane arrangement and lateral flow immunoassay device comprising the same

The present invention relates to a microarray device for the screening or the finding of protein inhibitors, to a method for the production thereof, and to a corresponding method for screening or finding protein inhibitors. The microarray device according to the invention comprises a solid supporting element having a support material, at least one protein immobilized thereon for which inhibitors are to be screened or found, and at least one known inhibitor of the at least one protein, the inhibitor being bound to the at least one protein and comprising a detectable label.

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Adelebsen, Germany

Denise Van Rossum