Amgen Inc.

Denise Lyn Andersen

Craig E Masse

Matthew M Weiss

Vinod Francis Patel

Brian K Albrecht

Stephen A Hitchcock

Holger Monenschein

Thomas T Nguyen

Patricia Lopez

Qiufen May Xue

Wenge Zhong

Yuan Cheng

Scott S Harried

Ted Charles Judd

Michael D Bartberger

Daniel La

James A Brown

Russell Graceffa

Lewis D Pennington

Thomas Nixey

Michael D Croghan

Bryant Yang

Charles Kreiman

Randall W Hungate

Stuart C Chaffee

Ryan Brown

Matthew R Kaller

Matthew K Kaller

James Brown

The present invention comprises a new class of compounds useful for the modulation of Beta-secretase enzyme activity and for the treatment of Beta-secretase mediated diseases, including Alzheimer's disease (AD) and related conditions. In one embodiment, the compounds have a general Formula I wherein A, B, R, R, R, i and j are defined herein. The invention also comprises pharmaceutical compositions including one or more compounds of Formula I, methods of use for these compounds, including treatment of AD and related diseases, by administering the compound(s) of Formula I, or compositions including them, to a subject. The invention also comprises further embodiments of Formulas II and III, intermediates and processes useful for the preparation of compounds of the invention.

Beta-secretase modulators and methods of use

Beta-Secretase modulators and methods of use

The present invention comprises a new class of compounds useful for the modulation of Beta-secretase enzyme activity and for the treatment of Beta-secretase mediated diseases, including Alzheimer's disease (AD) and related conditions. In one embodiment, the compounds have a general Formula I wherein R, W, B, R, R, R, i and j are defined herein. The invention also comprises pharmaceutical compositions including one or more compounds of Formula I, methods of use for these compounds, including treatment of AD and related diseases, by administering the compound(s) of Formula I, or compositions including them, to a subject. The invention also comprises further embodiments of Formulas II and III, intermediates and processes useful for the preparation of compounds of the invention.

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Simi Valley, CA, United States of America

Denise Lyn Andersen