USA As Represented by Secretary of the Navy

The Henry M. Jackson Foundation for the Advancement of Military Medicine Inc.

Genvec, Inc.

Denise Louise Doolan

Joseph T Bruder

C Richter King

Imre Kovesdi

Duncan L McVey

Daniel John Carucci

Keith Limbach

Douglas E Brough

Martha Sedegah

Joao Carlos Aguair

Walter R Weiss

Damodar R Ettyreddy

Thomas L Richie

Angela Trieu

Phillip L Felgner

The invention provides a method of identifying an antigen from a pathogen or a disease antigen comprising the use of an adenoviral vector array comprising two or more different adenoviral vectors, wherein each adenoviral vector comprises a nucleic acid sequence encoding a different antigen of a pathogen. The adenoviral vectors are administered to antigen presenting cells (APCs) in vitro or to an animal in vivo. The immunogenicity of the antigen is measured by screening for an immune response from effector T lymphocytes in vitro and by screening for the absence of pathogen-induced disease onset in vivo.

Malaria antigen screening method

The invention relates to antigens, associated with sterile immunity, and methods of their use, in an immunogenic formulation to confer an immune response against. The inventive antigens were identified by their association with sterile immunity against malaria.

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The invention provides a method of inducing an immune response against malaria in a mammal. The method comprises intramuscularly administering to a mammal a composition comprising a pharmaceutically acceptable carrier and either or both of (a) a first adenoviral vector comprising a nucleic acid sequence encoding acircumsporozoite protein (CSP) operably linked to a human CMV promoter, and/or (b) a second adenoviral vector comprising a nucleic acid sequence encoding aapical membrane antigen 1 (AMA-1) antigen operably linked to a human CMV promoter.

Adenoviral vector-based malaria vaccines

The invention provides adenoviral vectors comprising an adenoviral genome comprising heterologous antigen-encoding nucleic acid sequences, such asnucleic acid sequences, operably linked to promoters. The invention further provides a method of inducing an immune response against malaria in a mammal comprising administering the adenoviral vectors to the mammal.

Growing community of inventors

Camp Hill, Australia

Denise Louise Doolan