Wake Forest University

Denise Gibo

Waldemar Debinski

Hetal Pandya

Jill Wykosky

A compound comprising, in combination: a cell surface binding ligand or internalizing factor, such as an IL-13Rα2 binding ligand; at least one effector molecule (e.g., one, two, three or more effector molecules); optionally but preferably, a cytosol localization element covalently coupled between said binding ligand and said at least one effector molecule; and a subcellular compartment localization signal element covalently coupled between said binding ligand and said at least one effector molecule (and preferably with said cytosol localization element between said binding ligand and said subcellular compartment localization signal element). Methods of using such compounds and formulations containing the same are also described.

Multi-level specific targeting of cancer cells

A compound comprising, in combination: a cell surface binding ligand or internalizing factor, such as an IL-13R&#x3b1;2 binding ligand; at least one effector molecule (e.g., one, two, three or more effector molecules); optionally but preferably, a cytosol localization element covalently coupled between said binding ligand and said at least one effector molecule; and a subcellular compartment localization signal element covalently coupled between said binding ligand and said at least one effector molecule (and preferably with said cytosol localization element between said binding ligand and said subcellular compartment localization signal element). Methods of using such compounds and formulations containing the same are also described.

Nucleic acids encoding a fusion protein useful for multi-level specific targeting of cancer cells

A targeting peptide that specifically binds to an IL13 receptor (e.g., wherein said targeting peptide is not an IL13 fragment) is described. The targeting peptide is optionally conjugated to at least one effector molecule. In some embodiments, the peptide specifically binds to the IL13R&#x3b1;2 protein.

IL-13 receptor binding peptides

Compounds useful for multi-level specific targeting of cancer cells

Multi-level specific targeting of cancer cells with IL-13

The present invention provides compounds, compositions, and methods for detecting, diagnosing and treating cancers such as glioblastoma multiforme.

Growing community of inventors

Winston-Salem, NC, United States of America

Denise Gibo