Enterome

Patheon Api Services Inc.

Lund Biotechnology Pbc

Denis Viktorovich Arefyev

Chaminda Priyapushpa Gamage

George Yiannikouros

Panos Kalaritis

Michael P Cruskie, Jr

Joseph Chase Chewning

Marc Labelle

The invention relates to a process to prepare a compound of the following formula (I): (I), in which P represents a protective group of a hydroxyl function which is a &#x2014;CORgroup with Rrepresenting an aryl or a (CC)alkyl, R represents a hydrogen atom or a protective group of a terminal alkyne, from mannose, comprising the following steps: (a) protecting the 5 hydroxyl groups of the mannose by a protective group P; (b) coupling the protected mannose obtained at step (a) with a compound of the following formula (II). The present invention also relates to a compound of formula (IIIa). 

Process for preparing mannose derivatives

Methods of synthesizing prostaglandins, prostaglandin analogs and their synthetic intermediates are described. The methods can comprise metal-catalyzed metathesis reactions. Also provided are synthetic intermediates that can be used in the synthesis of the prostaglandins and prostaglandin analogs.

Synthesis routes for prostaglandins and prostaglandin intermediates using metathesis

The presently disclosed subject matter provides methods of preparing synthetic prostacyclin analogs, including Beraprost, either as racemic mixtures or as single stereoisomers. Also provided are novel synthetic intermediates for use in these methods.

Process for preparing synthetic prostacyclins

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Florence, SC, United States of America

Denis Viktorovich Arefyev