Institut De Recherche Pour Le Developpement (ird)

Centre National De La Recherche Scientifique

Université Pierre Et Marie Curie (Paris 6)

Institut De Recherche Pour Le Developpement

Universitè De Montpellier

Universidade Do Porto

Institut De Recherche Pour Le Development

Sorbonne Université

Denis Sereno

Ali Ladram

Bruno Oury

Jean-Loup Lemesre

Gilles Labesse

Jean-Francois Alexandre Guichou

Philippe Holzmuller

Pierre Nicolas

Rosa Milagros Corrales

Baptiste Vergnes

Ali Ouaissi

Anabela Cordeira Da Silva

Mireille Cavaleyra

Françoise Mathieu-Daude

Mohamed Amiche

Feten Abbassi

Thierry Foulon

Stephane Delbecq

Deborah Isabelle Garcia

Corinne Loeuillet

Déborah Isabelle Garcia

Jean-François Alexandre Guichou

Stéphane Delbecq

Jean-Baptiste Vergnes

Compounds of formula wherein n is 0, 1 or 2; X is and Ar is a benzyl substituted at the meta position by a Cto Calkoxy group, or a pharmaceutically acceptable salt thereof, for treating, preventing or inhibiting a parasitic disease, such as toxoplasmosis, in a subject are provided. Methods for preparing the compounds are also presented.

N-hydroxybenzamides as HDAC inhibitors for the treatment of parasitic diseases

The present invention relates to novel antimicrobial peptides, pharmaceutical compositions comprising said peptides, and the uses thereof, in particular as antimicrobial drugs, disinfectants, pesticides or preservatives. The present invention also relates to a transgenic plant expressing said novel peptides.

Analogues of temporin-SHa and uses thereof

The present invention relates to novel antimicrobial peptides, to pharmaceutical compositions comprising said peptides, and to the uses thereof, in particular as antimicrobial drugs, disinfectants, pesticides or preservatives. The present invention also relates to a transgenic plant expressing said novel peptides.

Analogs of temporin-SHa and uses thereof

Conserved polypeptides from protozoan parasitic species which are secreted through the endoplasmic reticulum/Golgi dependent secretory pathway, their identification and their use.

Method for the screening of conserved secreted proteins

The invention relates to nucleic acid constructions, characterized in that they comprise nucleic acids which are isolated in the sense position and which are capable of coding for an immunogenic protein of promastigotes or amastigotes of, said nucleic acids responding to one of the sequences SEQ ID No. 1, SEQ ID No. 2, SEQ ID No. 3, SEQ ID No. 4, SEQ ID No. 5 et SEQ ID No. 11 and coding for a protein respectively exhibiting a sequence SEQ ID No. 6, SEQ ID No. 7, SEQ ID No. 8, SEQ ID No. 9, SEQ ID No. 10 et SEQ ID No. 12. The invention can be used for over-expression of the genes ofcoding for an excretion/secretion antigen.

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The present invention relates to a protozoan strain of the family of the Trypanosomatidae the virulence of which is lower than that of the corresponding wild-type strain, characterized in that at least one copy of the SIR2 gene present in the genome of the strain is inactivated.

Protozoan strains of reduced virulence and use thereof

Growing community of inventors

Poussan, France

Denis Sereno