Crossject

Snpe Materiaux Energetiques

Biomerieux, Inc.

Snpe

Bio{acute Over (m)}erieux

Snpe Materlaux Energetiques

Denis Roller

Patrick Alexandre

Bernard Brouquieres

Bruno Colin

Patrick Broyer

Philippe Gautier

Georges Baud

Guy Delannoy

Patrick Cognot

Joel Lafforgue

Laurent D'Emmanuelle

Alain Navelier

Christian Perut

The technical field of the invention is that of needleless pre-filled disposable syringes, operating with a gas generator, and used for intradermal, subcutaneous and intramuscular injections, of a liquid active principle for therapeutic use in human and veterinary medicine. The inventive needleless syringes use a reservoir () consisting of a tube () closed by an upstream plug-piston () and a downstream plug-piston () between which is contained the liquid active principle. Said needleless syringes are characterized in that they are capable of injecting a variable amount of liquid active principle () by adapting, through displacement of the downstream plug-piston () in the tube () the volume included between the two plug-pistons () to the amount of active principle () to be injected.

Needleless syringe provided with modular reservoir

The invention relates to needleless syringe for injecting an active liquid principle. The inventive syringe comprises a container () closed by a movable shutter and containing the injectable liquid. Said container is initially insulated from an injector-receptacle provided with a cylinder bore () in which a downstream shutter is arranged and which comprises at least one protuberance reducing the section with respect to the upstream opening of the bore. The aim of said invention is to damp and prevent the downstream shutter bounce when it is disposed in the bore () of the receptacle.

Needleless syringe provided with a damping injector receptacle

The invention relates to a microsystem and a method for fabricating a microsystem. The pyrotechnic microsystem (') comprises a substrate having at least two separate electrical initiation zones, each of which provides separate electrical initiation of a pyrotechnic material deposited on the substrate. This microsystem (&#x2032;) is characterized in that the same pyrotechnic material deposit () covers both initiation zones, said deposit () produced on the substrate having a thickness sufficiently small for the initiation of the pyrotechnic material in the initiation zone to remain localized and not propagate to the other initiation zone, but sufficient to generate a specific gas quantity.

Pyrotechnic microsystem and method for fabricating a microsystem

The technical field of the invention is that of pre-filled and disposable needleless syringes, used for intradermal, subcutaneous and intramuscular injections of liquid active principle for therapeutic use in human and veterinary medicine. The inventive syringes () are mainly characterized in that they function with a pyrotechnic charge () consisting of a mixture of powder with high burning rate and a powder with low burning rate. Indeed, the combustion of the powder with a high burning rate enables to communicate instantly, through a piston (), a very high speed to the active principle (), whereas the combustion of the powder with a low burning rate enables to maintain a threshold pressure level to proceed with the injection, so as to ensure that the active principle () penetrates through the skin. Thus, the injection is properly and homogeneously without any loss of active liquid ().

Needleless syringe functioning with a double-composition pyrotechnic charge

The invention relates to a device for the electrical initiation of at least one pyrotechnic microcharge (), this device being characterized in that it comprises a support element having at least one conductive finger () connected to a first terminal of a central control unit (), a second terminal of said central control unit () being intended to be electrically connected to an electrically conductive support for the pyrotechnic microcharge (). The invention also relates to a microactuator () and a microsystem () that use such an initiation device.

Device for the electrical initiation of a pyrotechnic microcharge, and microsystem using such a device

The invention relates to an electrically-opened micro fluid-valve. The inventive valve comprises: at least one planar support (); at least one afferent microchannel (); at least one efferent microchannel (), said microchannels being arranged in the support (); such that at least one of the ends (and) thereof touch the inner face () of the support close to one another; at least one deposit () of a heat-sensitive material which is disposed on the inner face () of the support (); and at least one heating means (). According to the invention, the aforementioned deposit () of heat-sensitive material at least partially seals the space separating the ends (and) of the microchannels (and), thereby preventing same from intercommunicating. When the temperature of the above-mentioned heating means () is raised, the structure of the heat-sensitive material is altered, thereby at least partially opening the ends of the microchannels an the space therebetween, in order to enable communication between said microchannels and to restore the flow of the fluid.

Electrically opened micro fluid valve

The invention concerns the technical field of micro-actuators used for mechanical, chemical, electrical or thermal functions in microsystems, for microelectronic applications such as chips, or biomedical functions such as microfluidics integrating cards. The invention concerns a micro-actuator comprising a so-called main chamber, made in a solid support and containing a so-called main pyrotechnic charge, the main chamber being sealed and delimited by solid support walls and by a deformable membrane, such that the gases emitted by the combustion of the main pyrotechnic charge, enable the volume of the chamber to be increased by deforming the membrane while maintaining intact the solid walls of the main chamber. The invention is characterized in that it comprises means for evacuating the gases from the main chamber.

Double-effect pyrotechnic microactuator for microsystem and microsystem using same

The technical field of the invention is that of microactuators designed for mechanical, chemical, electrical or thermal functions in microsystems, for microelectronic applications such as chips, or biomedical applications such as cards incorporating microfluidics. The invention concerns a microactuator comprising a chamber machined in a solid support and containing a pyrotechnic charge. Said microactuator is essentially characterised in that the chamber is partly delimited by a deformable membrane, such that the gases emitted by combustion of the pyrotechnic charge enable to increase the volume of said chamber by deforming said membrane while maintaining intact the solid walls of the chamber.

Pyrotechnic microactuators for microsystems

A needleless syringe for injecting a liquid active principle. The syringe improves bioavailability by providing injection at two speed levels. The syringe includes a reservoir contained between an injector and push means subjected to the action of a gas generator. The push means including an end, directed towards the active principle, which forms a delivery head whereof the cross-section is smaller than the powering head cross-section, and the powering travel in the power cylinder is less than the height of the active principle reservoir.

Needleless syringe with two injection speed levels

The invention relates to a needleless syringe (), comprising the following' successively: a gas generator, a gas expansion chamber (), a means for retaining particles of the active agent and a tube () for ejecting said particles. The main characteristic of the inventive syringe is that the gas generator is a pyrotechnic generator (), comprising a pyrotechnic charge () which generates gas, a gas generator and an initiation device. The invention is also characterized in that the retaining means comprise at least one lid (), which is fixed to the ejection tube and is configured to break under the influence of the gases generated by the combustion of said charge ().

Needleless syringe which functions with the active agent being driven by a shocktube effect

The invention concerns a needleless syringe () comprising a trigger, a gas generator () prolonged by a gas expansion chamber (), a system for retaining particles and an ejection tube (). The invention is characterised in that the particles are housed outside the ejection tube conduit () and the gases cause the particles to reach inside said tube () by displacing a plunger (), prior to speeding them up by wave shock inside the tube ().

Needleless syringe functioning by shock-tube effect, with prior lateral retention of the active principle

The technical field of the invention is that of needleless syringes used for injecting active principles in powder form for therapeutic purposes. The invention concerns a needleless syringe ( ) comprising successively a gas generator ( ), a gas expanding chamber ( ), means for retaining active particles and an ejection tube ( ). The invention is characterised in that the particle retaining means consists of an inner seal ( ) having at least a cavity ( ), the inner seal ( ) serves both to contain the active principle and to generate a shock wave when it is ruptured.

Needleless syringe provided with an inner seal containing the active principle

The technical field of the invention is that of pre-filled and disposable needleless syringes, used for intradermal, subcutaneous and intramuscular injections of liquid active principle for therapeutic use in human and veterinary medicine. The inventive syringes ( ) are mainly characterised in that they function with a pyrotechnic charge ( ) consisting of a mixture of powder with high burning rate and a powder with low burning rate. Indeed, the combustion of the powder with a high burning rate enables to communicate instantly, through a piston ( ), a very high speed to the active principle ( ), whereas the combustion of the powder with a low burning rate enables to maintain a threshold pressure level to proceed with the injection, so as to ensure that the active principle ( ) penetrates through the skin. Thus, the injection is properly and homogeneously without any loss of active liquid ( ).

A device for igniting a solid pyrotechnic charge, including a conducting track, wherein the track consists of a conducting fluid deposited at least partially on the pyrotechnic charge, the pyrotechnic charge is deposited on a solid support and covers an empty cavity of the support, and the cavity forms a empty space between the pyrotechnic charge and the support.

Ignition device for pyrotechnic microcharges

The invention concerns the field of needless syringe for injecting liquid active principle for therapeutic purposes. It concerns a syringe wherein the active principle ( ) is initially placed between an injector ( ) comprising at least an injection duct ( ) contacted with the skin and a mobile wall ( ) separated from thrusting means ( ) displaced by gases of propellant generator ( ) pressurising and expelling the active principle. Said syringe aims at quickly providing a high expelling speed of the liquid to efficiently perforate the skin and improve bioavailability. Said syringe is characterised in that said thrusting means ( ) comprising temporary retention device ( ) deactivated by the operation of the propellant generator ( ).

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La Ferte Alais, France

Denis Roller