Centre National De La Recherche Scientifique

Aventis Pharma S.a.

Roussel Uclaf

Institut National De La Recherche Agronomique

Other

Dsm IP Assets B.v.

Rhone-poulenc Rorer S.a.

Hoechst Marion Roussel

Institut National Des Sciences Appliquees De Toulouse

Institute National Des Sciences Appliquees De Toulouse

Sanofi Mature IP

Bruno Dumas

Roberto Spagnoli

Denis Pompon

Xavier Chenivesse

Catherine Duport

Eric Lecain

Eric Degryse

Tilman Achstetter

Gilles Cauet

Aouatef Bellamine

Philippe Urban

Jacques Winter

Alain Perret

Magali Remaud-Simeon

Hans-Peter Hohmann

Isabelle Andre

Martin Lehmann

Sandrine Morel

Muriel Merkamm

Carine Bideaux

Jean-Louis Leroy

Christophe Cullin

Stephane Guillouet

Jillian Marc

Nathalie Gorret

Piotr Slonimski

Gilles Truan

Christel Boutonnet

Yoan Brison

Aude Laisne

Frederic Delorme

Frederic Paques

Emmanuelle Cambon

Julie Lesage

Wilfrid Boireau

Marie-Agnès Sari

Sophie Bombard

Yannick Malbert

Florence Bonnot

Fr&eacute;d&eacute;ric Delorme

Frédéric Pâques

Stèphane Guillouet

The invention relates to a method for producing derivatives of O-&#x3b1;-glucosylated flavonoid, comprising at least one step of incubating a glucansucrase with a flavonoid and at least one sucrose, the flavonoid being a flavonoid which is monohydroxylated or hydroxylated in a non-vicinal manner on the B cycle. The invention also relates to novel O-&#x3b1;-glucosylated flavonoid derivatives, and to the use thereof. 

Flavonoids O-A-glucosylated on the B cycle, method for the production thereof and uses

The invention relates to yeast cells modified to express a functional type I RuBisCO enzyme, and a class II phosphoribulokinase. The expression of these enzymes recreates a Calvin cycle in said yeasts in order to enable the yeasts to use carbon dioxide.

Yeasts modified to use carbon dioxide

This invention relates to the production of 7-dehydrocholesterol, 25-hydroxy-7-dehydrocholesterol, and 25-hydroxy ergosterol in yeast such as. It also relates to various enzymes catalyzing the reduction of the double bond at position 24 of lanosterol, dimethyl zymosterol, methyl zymosterol, zymosterol, cholesta-7, 24-dienol, or cholesta-5,7,24-trienol; or the hydroxylation at position 25 of ergosterol, 7-dehydrocholesterol, cholesta-8-enol, and cholesta-7-enol. It also relates to various nucleic acids encoding cholesterol C25-hydroxylases and sterol &#x394;24-reductases and their use to produce and hydroxylate 7-dehydrocholesterol or ergosterol. It also relates to the yeast strains so produced, and methods of making these sterols that include the steps of cultivaton a transformed yeast cell, and harvesting the resulting sterol(s).

Production of non-yeast sterols by yeast

The present invention pertains to a supramolecular structure based on i-motif tetramers of C&#x2014;X&#x2014;Coligonucleotides, wherein m and n are integers comprised between 2 and 9, and X is a linker such as A, T, G, a modified deoxynucleotide or a diol spacer. These supramolecular structures can be dissociated, when necessary, by a mere pH change. The present invention also relates to methods for obtaining such a supramolecular structure.

Multidimensional supramolecular structures essentially made of assembled i-motif tetramers

The invention concerns the production of cholesterol of the Fungi kingdom. More particularly, the invention concerns genetically modified Fungus independently producing cholesterol from a simple carbon source. The invention also concerns the use of the inventive Fungus for producing non-marked and marked cholesterol.

Desmosterol-producing yeast strains and uses thereof

The invention concerns the production of cholesterol in organisms of the Fungi kingdom. More particularly, the invention concerns genetically modified Fungus independently producing cholesterol from a simple carbon source. The invention also concerns the use of the inventive Fungus for producing non-marked and marked cholesterol.

Cholesterol-producing yeast strains and uses thereof

The present invention relates to genetically modified yeast strains autonomously producing, from a simple carbon source, steroids. The invention also relates to a method for producing steroids from such yeast strains.

Yeast strains autonomously producing steroids

The invention concerns novel biosensors, in particular a support for displaying nucleic acids and for detecting both the presence of nucleic acids in a sample and the linkage between proteins and nucleic acids, as well as the linkage between a ligand and a protein linked to a nucleic acid.

Supported double layer structure for displaying a nucleic acid associated with a protein

Yeast strains expressing human genes coding regulating cytochrome P450 expression, a method for making same and applications thereof are described.

Genetically engineered yeast strains

A nucleic acid sequence containing a sequence coding for a protein having a delta-5,7 sterol, delta-7 reductase activity, said nucleic acid being a DNA or an RNA, production process, strains of transformed yeasts and uses thereof.

Nucleic acid molecules encoding delta-5,7-sterol, delta-7 reductase from

A nucleic acid sequence containing a sequence coding for a protein having a .DELTA.-5,7 sterol, .DELTA.-7 reductase activity said nucleic acid being a DNA or an RNAg production process, strains of transformed yeasts and uses thereof

Arabidepsi thaliana proteins having

.DELTA..sup.5,7 -sterol reductase from arabidopsis thaliana

Yeast strains with stable integration of heterologous genes

Growing community of inventors

Gif sur Yvette, France

Denis Pompon