Koninklijke Philips Corporation N.v.

Denis Markov

Hans Marc Bert Boeve

A method for influencing and/or detecting magnetic particles in a region of action, magnetic particles and the use of magnetic particles is disclosed, which method comprises the steps of: &#x2014;introducing magnetic particles into a region of action, &#x2014;generating a magnetic selection field having a pattern in space of its magnetic field strength such that a first sub-zone having a low magnetic field strength and a second sub-zone having a higher magnetic field strength are formed in the region of action &#x2014;changing the position in space of the two sub-zones in the region of action by means of a magnetic drive field so that the magnetization of the magnetic particles change locally, &#x2014;acquiring signals, which signals depend on the magnetization in the region of action, which magnetization is influenced by the change in the position in space of the first and second sub-zone, wherein the magnetic particles comprise a core region and a shell region, the core region comprising a magnetic material, wherein the magnetic material of the core region is provided as a mainly metallic material of comparably high saturation magnetization, wherein the shell region comprises mainly a metal oxide material or a noble metal material.

Method for influencing and/or detecting magnetic particles in a region of action, magnetic particles and the use of magnetic particles

Magnetic Particle Imaging (MPI) requires high-performing tracer materials that are highly magnetic monodispersed particles with fast remagnetization behavior. Known separation techniques only allow for fractionation of magnetic particles based on differences in magnetic volume. Proposed is a separation method, which allows for separation of magnetic particles with respect to their dynamic response onto an oscillating high gradient magnetic field.

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Veldhoven, Netherlands

Denis Markov