Massachusetts Institute of Technology

The Brigham and Women's Hospital, Inc.

Denis Loginov

J Christopher Love

Todd Michael Gierahn

Viktor A Adalsteinsson

Alan Stockdale

Nathalie Y R Agar

Described herein are systems, methods, and apparatus for automatically identifying and recovering individual cells of interest from a sample of biological matter, e.g., a biological fluid. Also described are methods of enriching a cell type of interest. These systems, methods, and apparatus allow for coordinated performance of two or more of the following, e.g., all with the same device, thereby enabling high throughput: cell enrichment, cell identification, and individual cell recovery for further analysis (e.g., sequencing) of individual recovered cells.

Systems, methods, and apparatus for in vitro single-cell identification and recovery

Systems and methods for single cell culture and analysis by microscopy and matrix assisted laser desorption ionization mass spectrometry are disclosed. The systems and methods isolate a plurality of cells in a plurality of wells such that a predetermined number of the plurality of wells contain one and only one cell. The plurality of wells allow for optical interrogation of the cells and subsequent matrix assisted laser desorption ionizing of molecules within the cells.

Systems and methods for single cell culture and analysis by microscopy and MALDI mass spectrometry

Growing community of inventors

Dorchester Center, MA, United States of America

Denis Loginov