Assistance Publique-hopitaux De Paris

Societe De Conseils De Recherches Et D'applications Scientifiques (s.c.r.a.s.)

Centre National De La Recherche Scientifique

Université Paris Diderot-Paris 7

Université Paris-Sud 11

Occlugel

L'assistance Publique-hopitaux De Paris Etablissement Public De Sante

Denis Labarre

Alexandre Laurent

Laurence Moine

Michel Wassef

Nada Lambert

Hatem Fessi

Laurent Bedouet

Van Nga Nguyen

Minh Tam Baylatry

Anouk Bisdorf-Bresson

Jean-Pierre Saint-Maurice

Khelil Slimani

Cathy Ducos

Françis Diancourt

The present invention relates to a polymer obtained from the polymerization of: (i) at least one monomer of formula (I) (CH&#x2550;CR)CO&#x2014;K (I) wherein: K represents 0-Z or NH&#x2014;Z, Z representing (CRR)&#x2014;CH, (CH&#x2014;CH&#x2014;O)&#x2014;H, (CH&#x2014;CH&#x2014;O)&#x2014;CH, (CH)&#x2014;NRRwith m representing an integer from 1 to 30; R, R, R, Rand Rindependently represent H or a C1-C6 alkyl; and (ii) at least one bio-resorbable block copolymer cross-linker.

Implantable bio-resorbable polymer

An injectable biomaterial containing a non-aqueous solvent suitable for injection to a human being and nanoparticles made of a polymer that is insoluble in water and insoluble in the non-aqueous solvent, in which the nanoparticles are loaded with a drug or a biological agent. The injectable biomaterial is suitable for occluding normal or malformative blood vessels or non-circulating cavities, or for necrosing tumors.

Injectable biomaterial

A charged biomaterial including at least one first hydrophilic polymer, and superparamagnetic iron oxide particles complexed with a second hydrophilic polymer substantially identical to or different from the first hydrophilic polymer, wherein the superparamagnetic iron oxide particles complexed with the second hydrophilic polymer are distributed substantially homogeneously and substantially without aggregates in the first hydrophilic polymer. A process for preparing a charged biomaterial including forming an aqueous solution of hydrophilic monomers and superparamagnetic iron oxide particles complexed with a hydrophilic polymer including monomers substantially identical to or different from the hydrophilic monomers, polymerizing the solution and forming a polymer hydrogel in which are distributed substantially homogeneously and substantially without aggregates the superparamagnetic iron oxide particles complexed with the hydrophilic polymer.

Hydrophilic polymer biomaterial having a specific magnetic resonance imaging signal and process for the preparation of said biomaterial

The invention relates to cross-linked copolymers based on non cross-linked polycarboxylic copolymers, said non cross-linked copolymers containing at least one polysaccharide. The invention also relates to a process for the preparation of these copolymers and their use in particular as a support in pharmaceutical compositions.

Crosslinked copolymers based on non-crosslinked polycarboxylic copolymers

A cross-linked copolymer based on at least one non-crosslinked polycarboxylic polysaccharide and at least one second non-crosslinked polycarboxylic polymer which is not a polycarboxylic polysaccharide and a cross-linking agent having at least two amine functions.

Polycarboxylic based cross-linked copolymers

Growing community of inventors

Villebon, France

Denis Labarre