Wisconsin Alumni Research Foundation

Denis Kissounko

Samuel Helmer Gellman

Shannon S Stahl

Bernard Weisblum

Sarah Elizabeth Lee

Mehmet F Ilker

Christen Bell Smith

Firat Ilker

Disclosed is a method of making &#x3b2;-polypeptides. The method includes polymerizing &#x3b2;-lactam-containing monomers in the presence of a base initiator and a co-initiator which is not a metal-containing molecule to yield the product &#x3b2;-polypeptides. Specifically disclosed are methods wherein the base initiator is potassium t-butoxide, lithium bis(trimethylsilyl)amide (LiN(TMS)), potassium bis(trimethyl-silyl)amide, and sodium ethoxide, and the reaction is carried out in a solvent such as chloroform, dichloromethane, dimethylsulfoxide, or tetrahydrofuran.

Poly-&#x3b2;-peptides from functionalized &#x3b2;-lactam monomers and antibacterial compositions containing same

Poly-beta-peptides from functionalized beta-lactam monomers and antibacterial compositions containing same

The invention provides methods and reagents for the metathesis of secondary amides via a transacylation mechanism employing catalytic quantities of an imide initiator and a Br&#xf8;nsted base. Equilibrium-controlled exchange between various amide reactant pairs is demonstrated for substrates bearing a variety of N-alkyl and N-aryl substituents.

Catalytic metathesis of secondary amides

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Madison, WI, United States of America

Denis Kissounko