Syntex (u.s.a.) Inc.

Roche Palo Alto LLC

Hoffmann-la Roche Inc.

F. Hoffmann-la Roche Ag

Denis John Kertesz

David Bernard Smith

Eric Brian Sjogren

Leyi Gong

Robert Stephen Wilhelm

Michael Marx

Francisco Xavier Talamas

Jefferson Wright Tilley

Yimin Qian

Sung-Sau So

Sherrie Lynn Pietranico-Cole

Kshitij Chhabilbhai Thakkar

Nathan Robert Scott

Deborah C Reuter

Edvige Galeazzi Toscani

Keith Adrian Walker

Nancy-Ellen Haynes

Wylie Solang Palmer

Daisy Joe Du Bois

John O Gardner

Anthony Prince

Donald Roy Hirschfeld

Michael Martin

Beihan Wang

Norman H Dyson

David Berard Smith

David John Morgans, Jr

Michael J Klaus

James Patrick Dunn

John H Fried

Jean-Marc Lapierre

Minmin Yang

Sharada Shenvi Labadie

Christine E Brotherton-Pleiss

Paula Nanette Belloni

Michael G Roepel

Francisco X Talamas

Jim W Barnett

Aaron Bayne Miller

Nancy Ellen Haynes

Craig W Laughton

C Elliott Sigal

Chakk S Ramesha

Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as obesity, hyperlipidemia, hypercholesterolemia and diabetes and other related disorders and diseases, and may be useful for other diseases such as NASH, atherosclerosis, cardiovascular diseases, hypothyroidism, thyroid cancer and other disorders and diseases related thereto.

Thyroid hormone analogs

The present invention provides a process for the preparation 6-[3-(hetero)aryloxy-2-fluoro-benzyl]-2H-pyridazin-3-one compounds 1 where R2 is an optionally substituted aryl or an optionally substituted heteroaryl, Ris NO, NH, alkyl, halogen, or a function group readily derived therefrom and Ris hydrogen or alkyl. There also is provided a process for the preparation of phenylacetic acid compounds 2, wherein Rand Rare as defined previously and Ris hydrogen or alkyl, which are useful for the preparation of pyridazinone compounds.

Phenylacetic acid compounds

The present invention provides a process for the preparation of phenylacetic acid compounds 2 where Ris an optionally substituted aryl, Ris NO, NH, alkyl, halogen, or a function group readily derived there from and Ris hydrogen Calkyl, tert-butyl or benzyl The compounds of formula 2a are useful intermediates for the preparation of HIV reverse transcriptase inhibitors 

Process for preparing 3-aryloxy-phenylacetic acid compounds

This invention relates to certain cyclic amine derivatives of Formula (I)that are CCR-3 receptor antagonists, pharmaceutical compositions containing them, methods for their use and methods for preparing these compounds.

Cyclic amine derivatives-CCR-3 receptor antagonists

The invention provides compounds of Formula (I):wherein: R-R, A, L, and X have any of the values defined in the specification that are CCR-3 receptor antagonists, pharmaceutical compositions containing them, methods for their use, and methods and intermediates useful for preparing them.

Piperidine CCR-3 receptor antagonists

Piperazine CCR-3 receptor antagonists

The current invention provide novel compounds, methods of treating or preventing emphysema, cancer and dermatological disorders, pharmaceutical compositions suitable for the treatment or prevention of emphysema, cancer and dermatological disorders and methods for delivering formulations into the lung of a mammal suffering from emphysema, cancer and dermatological disorders.

Alkyl urea retinoid agonists

This invention relates to certain 2,4-substituted pyrrolidine derivatives that are CCR-3 receptor antagonists, pharmaceutical compositions containing them, methods for their use and methods for preparing these compounds.

2,4-substituted pyrrolidine derivatives-CCR-3 receptor antagonists

Piperidine quaternary salts- CCR- 3 receptor antagonists

This invention relates to certain cyclic amine derivatives of Formula (I)

Cyclic amine derivatives- CCR-3 receptor antagonists

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Mountain View, CA, United States of America

Denis John Kertesz