Firmenich Sa

Denis Jacoby

Lucia Bonomo

Fabrice Keller

Christian Chapuis

Peter Fankhauser

Jean-Jacques Riedhauser

Bessaa Neffah

Philippe Dupau

Philippe Miranda

Virginie Blanchard

Simone Chappuis

Harvey Randall

Catherine Gandara

Described herein is a process for the preparation of a mixture of compounds of formula having a weight ratio of the cis-diastereomers to trans-diastereoisomers higher than 1:1, where Rrepresents a Calkyl group, a Calkenyl group or a Calkynyl group, each optionally substituted with one or two of a Calkyl alkoxy ether group and/or a Calkyl carboxylester group and Rrepresents a Calkyl, a Calkenyl or a Calkynyl group, each optionally substituted with a Calkyl alkoxy ether group, a carboxylic acid group or a Calkyl carboxylester group and compounds suitable in the process.

Process for the preparation of cis-alpha,beta substituted cyclopentanones

The present invention relates to the field of organic synthesis and more specifically it concerns a process for preparing compound of formula (I) catalyzed by a nickel complex. The compound of formula (II) is also part of the invention.

Process for preparing diene

Described herein is a process for preparing a compound of formula (I) starting from a compound of formula (II) where the process is catalyzed by a metal complex.

Process for preparing bicyclic enolether

The present invention relates to the field of organic synthesis and more specifically it concerns a process for the dehydrogenation of compound of formula (I) catalyzed by palladium (Pd) in elemental metallic form.

Dehydrogenation reaction

Described herein is a process for preparing a compound of formula (I) starting from a compound of formula (II), where the process is catalyzed by a Ruthenium complex.

A method for producing certain 2-alkoxy-ethanol derivatives by depolymerising oligomeric or polymeric polyglycol derivatives in the presence of alcoholate or 1,3-diketonate derivatives of zirconium, titanium, aluminum or molybdenum.

Selective preparation of some 2-alkoxy-ethanol derivatives

The invention relates to a process for the preparation, in a single step, of substituted 2-cyclopenten-1-ones by reacting a substituted enone with an aldehyde in the presence of a catalytic system. The catalytic system consists of a metal complex, such as a Ti(Cl)(alkoxy), and a co-ingredient, such as a carboxylic acid anhydride or an anhydrous salt.

Synthesis of cyclopentenones

The present invention relates to a process for the carbon-carbon double bond isomerisation of a 2-alkyl-cyclohex-3-enyl alkyl or alkenyl ketone into a mixture comprising the corresponding 2-alkyl-cyclohex-2-enyl ketones and the corresponding 2-alkylene-cyclohexyl ketones, using as catalyst a ruthenium complex obtainable by the reaction of an appropriate ruthenium organometallic precursor and an acid.

Process for the isomerisation of a cyclohexenyl alkyl or alkenyl ketone

The invention relates to a catalytic system for use in a process for the preparation, in a single step, of enones by an aldol condensation of a ketone, such as a gem-dimethyl cyclohexylethanone or gem-dimethyl cyclohexenylethanone derivative, with an aldehyde in the presence of a novel catalytic system and a co-ingredient, such as a carboxylic acid anhydride or an anhydrous salt, and without the pre-formation of an enolate. The catalytic system is a metal complex, such as a [(Cl)(alkoxy)Ti] or [(Cl)(alkoxy)Zr] complex where n is 1 to 3.

Catalytic system for aldol reactions

The invention relates to a process for the preparation, in a single step, of enones by an aldol condensation of a ketone, such as a gem-dimethyl cyclohexylethanone or gemdimethyl cyclohexenylethanone derivative, with an aldehyde in the presence of a novel catalytic system and a co-ingredient, such as a carboxylic acid anhydride or an anhydrous salt, and without the pre-formation of an enolate. The catalytic system is a metal complex, such as a [(Cl)(alkoxy)Ti] or [(Cl)(alkoxy)Zr] complex where n is 1 to 3.

The present invention relates to the field of organic synthesis and more specifically to a process for the preparation of Michael-adducts, as defined below, by reacting a &bgr;,&bgr;- or a &agr;,&bgr;-disubstituted, or a &agr;,&bgr;,&bgr;-trisubstituted, &agr;,&bgr;-unsaturated ketone (I) with a &bgr;-ketoester or a &bgr;-diketone (II) in presence of a suitable catalyst of formula M(X) , according to scheme 1:

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Nyon, Switzerland

Denis Jacoby