Societe Civile Bioprojet

Bioprojet

Institut National De La Sante Et De La Recherche Medicale

Bioproject

Societe Civile Bioproject

Other

Denis Danvy

Jean-Charles Schwartz

Jeanne-Marie Lecomte

Pierre Duhamel

Lucette Duhamel

Thierry Monteil

Jean-Christophe Plaquevent

Claude Gros

Marc Capet

Nadine Noel

Philippe Robert

Nicolas Levoin

Isabelle Berrebi-Bertrand

Bruno Giros

Thierry Calmels

Xavier Ligneau

Olivier Chamard

Serge Piettre

Olivier Labeeuw

Xavier Billot

Helene Greciet

Christophe Lusson

Stéphane Krief

Marcel Morvan

G&eacute;rard Coquerel

Marie-No&euml;lle Petit

Nadine Noel-Lefebvre

The present patent application concerns new ligands of the H4-receptor, their process of preparation and their therapeutic use.

Benzazole derivatives as histamine H4 receptor ligands

The present patent application concerns new ligands of the H4-receptor of formula (I), their process of preparation and their therapeutic use. 

The invention relates to compounds of the general formula (I): to the process for preparing them, and to the use thereof as a therapeutic agent. 

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The invention relates to compounds of the general formula (I): to the process for preparing them, and to the use thereof as a therapeutic agent having the property of being selective ligands for the dopamine D3 receptor. These selective D3 ligands are useful as medicines in neuropsychiatry, in particular in the treatment of psychotic or depressive states, or in the treatment of motor disorders, such as dyskinesia or essential tremor. They are furthermore useful in the treatment of dependency on nicotine, cocaine, alcohol, opioids and for facilitating withdrawal in drug-dependent individuals.

Arylpiperaszine derivatives, to the process for the production thereof and to the use thereof as therapeutic agents

The invention relates to compounds which constitute a class of medicaments which have an anti-inflammatory activity and which act by inhibiting leukotriene A(LTA), and enzyme which is responsible for the biosynthesis of leukotriene LTB, a major proinflammatory mediator. The invention also relates to therapeutic anti-inflammatory, applications of these compounds as well as for methods of preparing these compounds.

The invention concerns compounds inhibiting LTAhydrolase of formula (I). The invention also concerns their therapeutic, in particular anti-inflammatory, applications.

LTA4 hydrolase inhibitors

Process for synthesizing N-(mercaptoacyl) amino acid derivatives from alpha-substituted acrylic acids

The subject of the present invention is the various polymorphic forms I, II, III, IV of benzyl (S,S)-2-(2-acetylsulphanylmethyl-3-benzo&lsqb;1,3&rsqb;dioxol-5-ylpropionyl-amino)propionate, hereinafter called Fasidotril, their methods of preparation and novel pharmaceutical compositions containing them.

Polymorphic forms of fasidotril, their methods of preparation and pharmaceutical compositions comprising them

The invention concerns LTA hydrolase inhibiting compositions of formula (1) as set forth below. It also concerns their therapeutic, in particular anti-inflammatory, applications.

Process for the asymmetric synthesis of S-acyl derivatives of

Process for the synthesis of .alpha.-substituted acrylic acids of general formula (I) and their application to the synthesis of N-(mercaptoacyl)aminoacid derivatives of formula (II). ##STR1##

Process for the synthesis of .alpha.-substituted acrylic acids and their

Amino acid derivatives of formula (Ia) and (Ib) and pro-drugs thereof containing a group responsible for chelating the zinc atom of enkephalinase and angiotensin convertase enzymes are disclosed as inhibitors of these enzymes.

Amino acids derivatives, the process for their preparation and their

Process for the synthesis of a-substituted acrylic acids and their application. Process for the synthesis of a-substituted acrylic acids of general formula (I) and their application to the synthesis of N- (mercaptoacyl) aminoacid derivatives of formula (II). ##STR1##

Amino acid derivatives having both enkephalinase and ACE inhibiting properties corresponding to the formula: ##STR1##

Amino acid derivatives, the process for their preparation and their

New amino acid derivatives, processes for their preparation, and their therapeutic application are described. These amino acid derivatives correspond to the general formulae ##STR1## These derivatives may be used as medicaments which exhibit an enkephalinase-inhibitory activity.

Growing community of inventors

Yvetot, France

Denis Danvy