Venatorx Pharmaceuticals, Inc.

Denis Daigle

Christopher J Burns

Bin Liu

Robert E Lee Trout

Daniel C Pevear

Daniel McGarry

Randy W Jackson

Jodie Hamrick

Steven Armen Boyd

Jiangchao Yao

Eugen F Mesaros

Guo-Hua Chu

Stephen M Condon

Allison L Zulli

Matthew Lucas

Daniel Mcgarry

Zhenrong Xu

Timothy Henkel

Luigi Xerri

Cullen L Myers

Robert E Trout

Described herein are certain boron-containing compounds, compositions, preparations and their use as modulators of the transpeptidase function of bacterial penicillin-binding proteins and as antibacterial agents. In some embodiments, the compounds described herein inhibit penicillin-binding proteins. In certain embodiments, the compounds described herein are useful in the treatment of bacterial infections.

Penicillin-binding protein inhibitors

Described herein are compounds and compositions that modulate the activity of beta-lactamases. In some embodiments, the compounds described herein inhibit beta-lactamase. In certain embodiments, the compounds described herein are useful in the treatment of bacterial infections.

Beta-lactamase inhibitors

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Street, MD, United States of America

Denis Daigle