Universitéde Montreal

Hopital Maisonneuve-rosemont

Valorisation-recherche, Limited Partnership

Rsem, Limited Partnership

Adaerata, Limited Partnership

British Columbia Caner Agency Branch

Denis-Claude Roy

Luc Villeneuve

Nestor Molfino

Martin Guimond

Guy Sauvageau

Keith Richard Humphries

Nathalie Beslu

Nestor A Molfino

Compositions and methods for reducing or preventing graft-versus-host disease associated with allogeneic stem cell transplantation are described. A method includes harvesting hematopoietic cells from a patient with an immunologic disorder and harvesting hematopoietic cells from a donor. The harvested hemaptopoietic cells from the patient and the donor are mixed ex vivo for a period of time sufficient to activate lymphocytes within the hematopoietic cells harvested from the donor such that an immune reaction occurs and an activated portion and an unactivated portion is produced. A rhodamine B derivative is then added to the mixture of cells and the mixture is irradiated at a suitable wavelength and intensity for the selective destruction and/or inactivation of the activated portion without substantially affecting the unactivated portion or causing systemic toxicity in said patient. The irradiated cells are then infused into the patient.

Rhodamine derivatives for photodynamic diagnosis and treatment

The present invention relates to the use of the photoactivable derivatives for the photodynamic treatment for the selective destruction and/or inactivation of immunologically reactive cells without affecting the normal cells and without causing systemic toxicity for the patient, wherein appropriate intracellular levels of said derivatives are achieved and irradiation of a suitable wavelength and intensity is applied.

A polypeptide, the amino acid sequence of which comprises a sequence as set forth in SEQ ID NO:2, including at least one mutation within the degron domain of the polypeptide encompassed between positions 1 and 35 of the sequence, wherein said at least one mutation reduces the susceptibility of the polypeptide to ubiquitin-proteasome degradation.

Mutated HOXB4 proteins with improved stability, and methods of use thereof

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Montreal, Canada

Denis-Claude Roy