Thermo Fisher Scientific (bremen) Gmbh

Denis Chernyshev

Alexander Alekseevich Makarov

Jan-Peter Hauschild

Eduard V Denisov

Wilko Balschun

Amelia Corinne Peterson

Christian Thoeing

Nicolaie Eugen Damoc

Aivaras Venckus

Jen-Peter Hauschild

Erik Couzijn

Method and system of mass spectrometry is provided. The method comprises performing a first and a second MS1 scans on precursor ions produced by ionising a sample. The first MS1 scan comprises mass analysing a first set of the precursor ions transported to a mass analyser using an ion transport device operated at a first setting. The second MS1 scan comprises mass analysing a second set of the precursor ions transported to a mass analyser using the ion transport device operated at a second setting. Energies imparted on the precursor ions by the ion transport device are different in the first and second settings. Based on intensities of mass spectral peaks of the first and second MS1 scans, a mass spectral peak in at least one of the first MS1 scan or the second MS1 scan indicative of a precursor ion mass spectral peak is determined.

Methods and apparatus for mass spectrometry

The present invention provides a mass spectrometer comprising a first ion trap, a second ion trap, a lens stack for directing ions from the first ion trap to the second ion trap and a housing. The first ion trap is arranged to form a linear or curved potential well and the second ion trap is an electrostatic ion trap, for example, an orbital ion trap, arranged to form an annular potential well. The mass spectrometer further comprises a unitary insert comprising a first cavity which holds the lens stack and a second cavity which holds the second ion trap, wherein the insert is inserted within the housing.

Mass spectrometer using unitary insert between first and second ion traps

The present invention provides an electrode arrangementfor an ion trap, ion filter, an ion guide, a reaction cell or an ion analyser. The electrode arrangementcomprises an RF electrode' mechanically coupled to a dielectric material. The RF electrode′ is mechanically coupled to the dielectric materialby a plurality of separatorsthat are spaced apart and configured to define a gap between the RF electrode′ and the dielectric material. Each of the plurality of separatorscomprises a projecting portionand the dielectric materialcomprises corresponding receiving portionssuch that on coupling of the RF electrode′ to the dielectric material, the projecting portionof each separatoris received within the corresponding receiving portiona of the dielectric material. The present invention also relates to an ion trap comprises the electrode arrangementand a method of manufacturing the electrode arrangement

Electrode arrangement

The present invention provides an electrode arrangement' for an ion trap, ion filter, an ion guide, a reaction cell or an ion analyser. The electrode arrangement&#x2032; comprises an RF electrode&#x2032; mechanically coupled to a dielectric material. The RF electrode&#x2032; is mechanically coupled to the dielectric materialby a plurality of separatorsthat are spaced apart and configured to define a gap between the RF electrode&#x2032; and the dielectric material. Each of the plurality of separatorscomprises a projecting portionand the dielectric materialcomprises corresponding receiving portionssuch that on coupling of the RF electrode&#x2032; to the dielectric material, the projecting portionof each separatoris received within the corresponding receiving portionof the dielectric material. The present invention also relates to an ion trap comprises the electrode arrangement&#x2032; and a method of manufacturing the electrode arrangement

Disclosed herein is an ion supply system, having an ion source emitting ions into a fore vacuum chamber, an ion transport device having stacked electrodes arranged in the fore vacuum chamber, a control system supplying an oscillatory voltage to the electrodes of the ion transport device and a vacuum chamber, arranged downstream from the ion transport device. A vacuum gauge is arranged in the vacuum chamber. The pressure signal of the vacuum gauge is supplied to the control system supplying the oscillatory voltage to electrodes of the ion transport device. The control system adjusts the amplitude of the oscillatory voltage in accordance with the pressure signal.

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Bremen, Germany

Denis Chernyshev