Pfizer Corporation

Zoetis Services LLC

Pfizer Products Inc.

Zoetis LLC

Denis Billen

David Morris Gethin

Kim Thomas Hall

Nathan Anthony Logan Chubb

Lee Richard Roberts

Nigel Derek Arthur Walshe

Douglas James Critcher

Jessica Boyle

Graham Michael Kyne

Timothy Lee Stuk

Valerie Ann Vaillancourt

Michael P Curtis

Sanjay Menon

Matthew Joseph Birchmeier

Nathan Anthony Chubb

Ronald J VanderRoest

Sean David William Greenwood

Vageesha Warnajith Liyana Gunawardana

Valerie Sue Westrick

Nigel Derek Walshe

Described herein are improved processes for the preparation of the 7H-pyrrolo[2,3-d]pyrimidine compound, N-methyl-1-{trans-4-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclohexyl}-methanesulfonamide, intermediates thereof, and veterinary acceptable salts thereof.

Process for preparing 7H-pyrrolo[2,3-D]pyrimidine compounds

The present invention relates to novel crystalline modifications of 1-(5'-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoro-methyl)-4,5-dihydroisoxazol-3-yl)-3&#x2032;H-spiro[azetidine-3,1&#x2032;-isobenzofuran]-1-yl)-2-(methylsulfonyl)ethanone. The present invention also describes compositions and methods of treating a parasitic infection or infestation in an animal in need thereof. The present invention also relates to processes for making the crystalline forms.

Crystalline forms of 1-(5'-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoro-methyl)-4,5-dihydroisoxazol-3-yl)-3&#x2032;H-spiro[azetidine-3,1&#x2032;-isobenzofuran]-1-yl)-2-(methylsulfonyl) ethanone

The invention recites spirocyclic isoxazoline derivatives of Formula (V.1), Formula (V.2), Formula (V.1.1), and Formula (1) stereoisomers thereof, veterinarily acceptable salts thereof, compositions thereof, processes for making, and their use as a parasiticide in an animal. The variables A, V, Z, W, W, W, W, Y, X, R, R, R, R, R, R, n, and '' are as described herein.

Spirocyclic isoxazoline derivatives as antiparasitic agents

This invention relates to a combination product comprising a compound of formula I wherein X, R, R, R, R, R, R, Rand Rare as described herein, and one or more further biologically active compounds as described herein, particularly anti-parasitic agents.

Substituted arylpyrazoles

This invention relates to a range of 1-aryl-4-cyclopropylpyrazoles in which the cyclopropyl ring is substituted at the angular position, and pharmaceutically acceptable salts and solvates thereof, to compositions comprising such compounds, processes to their synthesis and their use as parasiticides.

This invention relates to a combination product comprising a range of 1-aryl-4 -cyclopropylpyrazoles in which there is at least one fluorine attached to the cyclopropyl ring, and one o more further therapeutic agents, particularly anti-parasitic agents.

This invention relates to a range of 1-aryl-4-cyclopropylpyrazoles in which there is at least one fluorine attached to the cyclopropyl ring, to compositions comprising such compounds, processes to their synthesis and their use as parasiticides.

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Sandwich, United Kingdom

Denis Billen