Pfizer Corporation

Delvin R Knight, Jr

Banavara L Mylari

Peter J Oates

W Ross Tracey

Thomas A Beyer

E Roy Pettipher

Bruce A Lefker

Kimberly O Cameron

The present invention provides a method of treating hypertension, liver failure, loss of patency of ductus arteriosus, glaucoma or ocular hypertension in a patient, comprising administering to the patient a therapeutically effective amount of a selective EPreceptor agonist of Formula I or a prodrug thereof, a pharmaceutically acceptable salt of the selective EPreceptor agonist or prodrug or a stereoisomer or diastereomeric mixture of the EPreceptor agonist, prodrug or salt, wherein the variables X, Z, Q,, and Rare as defined in the specification.

Methods of treatment with selective EP4 receptor agonists

A method of preventing non-cardiac tissue damage resulting from ischemia, comprising administering to a patient in need of such treatment an effective amount of an aldose reductase inhibitor.

Method of reducing tissue damage associated with non-cardiac ischemia

A method of preventing tissue damage resulting from ischemia, comprising administering to a patient in need of such treatment an effective amount of a sorbitol dehydrogenase inhibitor.

Method of reducing tissue damage associated with ischemia

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Ledyard, CT, United States of America

Delvin R Knight, Jr