Université Paris Descartes

Université D'auvergne

Delphine Rigault

Jean-Philippe Pin

Francine Acher

Alain Eschalier

Jérôme Busserolles

Cyril Goudet

Bruno Commare

Isabelle Lemasson

Sara Cesarini

The invention relates to hypophosphorous acid derivatives of formula (I) wherein &#x2014;X is H or OH, &#x2014;R represents one or several radicals R-R, identical or different, two of R-Roptionally occupying the same position on the phenyl group, one to four of R-Rbeing H and the others being selected in the group comprising -0-(CH)&#x2014;COOH; &#x2014;S&#x2014;(CH)&#x2014;COOH; &#x2014;NH&#x2014;(CH)&#x2014;COOH; -0-(CH,R')&#x2014;COOH; &#x2014;O&#x2014;(CH)&#x2014;OH; OR&#x2032;, &#x2014;R&#x2032; being a C-Calkyl radical; &#x2014;OH; &#x2014;COOH; halogen, particularly &#x2014;F, &#x2014;CI, &#x2014;Br, &#x2014;I, &#x2014;CF; &#x2014;OCF; &#x2014;N0; &#x2014;CH&#x2550;CH&#x2014;COOH; &#x2014;(CH)&#x2014;COOH; O&#x2014;(CH)&#x2014;P0H; O&#x2014;(CF)&#x2014;P0H; O&#x2014;(CH)&#x2014;S0H; O&#x2014;(CH)&#x2014;CONHOH; O&#x2014;(CH)-tetrazol; O&#x2014;(CH)-hydroxyisoxazol&#x2014;n=1 to 5, preferably 1-3; said hypophosrous acid derivatives being diastereoisomers or enantiomers. 

Hypophosphorous acid derivatives having antihyperalgic activity and biological applications thereof

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Viroflay, France

Delphine Rigault