Sofradim Production

Delphine Petit

Xavier Bourges

Yves Bayon

Nicolas Prost

Suzelei Montanari

The present invention relates to a surgical anti-adhesion barrier film comprising an oxidized collagen and a polyphosphate compound and to a surgical implant comprising a prosthetic fabric and such a film.

Method for preparing an anti-adhesion barrier film

The present invention relates to a prosthetic fabric () comprising an arrangement () of yarns that define at least first and second opposite faces () for said fabric, said fabric comprising on at least said first face, one or more barbs () that protrude outwards relative to said first face, said fabric being covered, at least partly, on said second face with a microporous layer made of a bioresorbable material, said barbs being covered with a coating made of a water-soluble material. The invention also relates to a process for obtaining such a fabric and to prostheses obtained from such a fabric.

Gripping fabric coated with a bioresorbable impenetrable layer

The present invention relates to a method for preparing a surgical anti-adhesion barrier film comprising the following steps: a&#xb0;) a first solution, comprising an oxidized collagen is prepared, b) a polyphosphate compound is added to the solution of a) in a quantity so as to obtain a concentration of polyphosphate ranging from 0.007 to 0.7 %, by weight, with respect to the total weight of the solution, c) the pH of the solution obtained in b) is adjusted to about 9 by addition of a base or to about 5.1 by addition of an acid, d) a diluted solution is prepared by adding water to solution of c), e) a first layer of solution obtained in c) is casted on an inert support, f) before complete gelation of the layer obtained in d), a second layer, of diluted solution obtained in d) is applied on top of said first layer and let to gelify, g) the gelified first and second layers are dried to obtain a film. The invention further relates to a film obtainable by such a method and to a surgical implant comprising a prosthetic fabric and such a film.

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Montanay, France

Delphine Petit