Nankai University

Neosheng (tianjin) Biotechnology Co., Ltd

Deling Kong

Meifeng Zhu

Wen Li

Guangzhou Song

Kai Wang

Zhen Zhang

Zhuangzhuang Yang

Songdi Wang

Wenqian Cong

Xianhao Dong

Yueyue Yang

An acellular matrix woven material, a preparation method and an application thereof are provided. The acellular matrix woven material is prepared by combining 3D printing with weaving. At the same time, also provided are the acellular matrix woven material prepared by the preparation method and its application in preparing tissue engineering scaffold materials.

Acellular matrix woven material, preparation method and application thereof

The present disclosure discloses a preparation method and application of decellularized extracellular matrix tissue paper, and belongs to the technical field of regenerative medicine. The preparation method includes the following steps: (1) preparing decellularized extracellular matrix materials; (2) preparing tissue paper: homogenizing and stirring the prepared decellularized extracellular matrix materials, then, placing the obtained homogenates on a flat-bottom filter screen to filter out water, standing and air-drying the filtered homogenates, and freeze-drying the homogenates to obtain the tissue paper; (3) cross-linking the tissue paper: cross-linking the tissue paper in a cross-linking solution; and (4) freeze-drying or stacking and compacting the cross-linked tissue paper. According to the present disclosure, the decellularized extracellular matrix tissue paper with tissue specificity is prepared by a traditional paper-making technology combined with a freeze-drying technology.

Preparation method and application of decellularized extracellular matrix tissue paper

A vascularized cardiac organoid with a chamber structure and its preparation method is presented. The cardiac organoids have a unique chamber structure, which includes a myocardium wall. Within the cardiac organoids, a vascular network is developed, enclosed within the myocardium wall. This vascular network is composed of endothelial cells surrounded by smooth muscle cells, forming a network of branched tubular structures. The presence of vasculature significantly promotes the arrangement of the myocardium, enhances the organization of the cardiac cytoskeleton, and promotes the consistency and beating frequency of cardiac cells. The vasculature facilitates the growth and size increase of the cardiac organoids.

Vascularized cardiac organoid with a chamber structure and its preparation method

The present disclosure discloses a composite tubular material and a preparation method thereof. The tubular material is prepared from extracellular matrix and directionally arranged synthetic polymer fibers through compounding; the synthetic polymer fibers serve as an internal skeleton, a fiber diameter ranges from 1 μm to 2000 μm, a fiber angle ranges from 0° to 180°, and a wall thickness ranges from 1 μm to 1000 μm; and extracellular matrix components are obtained from human or animal tissue through decellularization. According to the present disclosure, the tubular material with bioactivity and excellent mechanical properties can be prepared from the synthetic polymer and the natural material extracellular matrix through compounding; the synthetic polymer fibers with controllable fiber angle and diameter serve as the internal skeleton of the tubular material, and accordingly the tubular material has the mechanical properties of resistance to bending and squeezing.

Composite tubular material prepared from extracellular matrix and synthetic polymer, and preparation method thereof

Disclosed is a bending-resistant nerve catheter and a preparation method and application thereof, and relates to the technical field of tissue engineering materials. The catheter of the present application includes an inner layer, a middle layer and an outer layer, and each layer uses raw materials of biodegradable polymers; among them, the inner layer includes a smooth surface inner layer, an oriented microchannel inner layer or a fibrous inner layer, the middle layer is a fibrous middle layer with crossing angles, the middle layer is prepared by entangling micron fibers with a certain angular arrangement, and the outer layer is made of randomly entangled polymer fibers and is tightly bonded to the middle layer.

Growing community of inventors

Tianjin, China

Deling Kong