Iowa State University Research Foundation Inc

Harrisvaccines, Inc.

Chromalloy American Corporation

University of Iowa Research Foundation

The United States Government As Represented by the Department of Veterans Affairs

Burns-biotec Laboratories, Inc.

Delbert Linn Harris

Matthew M Erdman

Kurt Iver Kamrud

John Dustin Loy

Lyric Colleen Bartholomay

Ed Scura

Robert A Goodnow

Robert D Glock

Joann M Kinyon

Kent Jay Schwartz

Nakhyung Lee

Matthew Erdman

David M Lubaroff

Jonathan Fowler Smith

A method of vaccinating a subject is provided, where a cancer protective response is produced. A first vaccine comprises an adenovirus vector comprising at least one nucleic acid molecule that produces a cancer protective response is administered, followed by one or more second vaccines comprising an alphavirus replicon particle comprising RNA comprising or produced from the nucleic acid molecule. In an embodiment the cancer is prostate cancer.

Cancer vaccines and methods of producing and using same

A method of quickly producing a vaccine for a biotype of pathogenic microorganism is described, where a nucleic acid molecule or fragment thereof is obtained from a biological sample from an animal exposed to the microorganism, a protective molecule is prepared based on the nucleic acid molecule of interest or fragment thereof, and administered to an animal which has been or is as risk of being exposed to the microorganism. A protective response to the biotype of the microorganism is obtained in the animal.

Method of rapidly producing improved vaccines for animals

The invention relates to a polypeptide of a protective antigenic determinant (PAD polypeptide) of porcine reproductive and respiratory syndrome virus (PRRSV) and nucleic acids encoding a PAD polypeptide. The PAD polypeptide and nucleic acids encoding a PAD polypeptide are useful in the development of antibodies directed to PAD, vaccines effective in providing protection against PRRSV infection, and diagnostic assays detecting the presence of PAD antibodies generated by a PAD-specific vaccine. The invention also discloses methods of generating antibodies to PAD, for vaccinating a pig to provide protection from PRRSV infections, a method of preparing the vaccine, a method of treating PRRSV infections in a pig, and a method of detecting antibodies to PAD of PRRSV.

Identification of protective antigenic determinants of porcine reproductive and respiratory syndrome virus and uses thereof

Compositions and methods of protecting aquatic invertebrates from disease is shown. In one embodiment, dsRNA or antisense RNA to a nucleic acid molecule of the disease-causing microorganism is prepared and delivered to the animal. In another embodiment, a nucleic acid molecule of the disease-causing microorganism is delivered to the animal. In another embodiment, the RNA or nucleic acid molecule is delivered to the animal by replicon particle. In a further embodiment, the protective molecule is delivered to the digestive tract of the animal. Protection from disease is obtained.

Methods and compositions to protect aquatic invertebrates from disease

The invention provides compositions comprising Felix 0-1 Phage (F01 phage) in a an-acceptable carrier and methods of administering the compositions to a livestock animal to reduce or prevent dissemination of Salmonella.

Compositions and methods for reducing the amount of salmonella in livestock

The resistance of swine to dysentery infection is increased by the combined parenteral and oral administration of killed cells of Treponema hyodysenteriae (T. hyo.). A sensitizing parenteral dose of the T. hyo. is administered first and, after delay of a number of days, the swine are given a feed containing the killed T. hyo. cells adsorbed on a porous carrier. The method is particularly applicable for the protection of young, growing pigs against swine dysentery infection.

Method of combined parenteral and oral vaccination for swine dysentery

A combination vaccine for increasing the resistance of swine to dysentery infection comprises killed cells of a virulent isolate of Treponema hyodysenteriae in combination with concentrated killed cells of Bacteroides vulgatus, or Fusobacterium necrophorum, or mixtures thereof. This combination vaccine can be adapted for either oral or parenteral administration. For parenteral administration preferably only Bacteroides vulgatus is used in combination with Treponema hyodysenteriae. The oral vaccine is enteric-coated.

Growing community of inventors

Ames, IA, United States of America

Delbert Linn Harris