Histosonics, Inc.

University of Michigan

Xoran Technologies, Inc.

Escapes Network LLC

Armzreach, Inc.

Ring Bus Americas LLC

Dejan Teofilovic

Jonathan M Cannata

Aleksandra Rakic

Joshua Stopek

Ryan M Miller

Alexander P Duryea

Zeljko Mladenovic

Charles A Cain

Russell Carl Jahnke

William W Roberts

Thomas W Davison

Timothy L Hall

Miodrag Rakic

William Van Kampen

James A Bertolina

Uros Tomanovic

Adam D Maxwell

Zhen Xu

Robert A Oklejas

J Brian Fowlkes

Michael Thomas Kusner, Jr

Dragan Cerovcevic

Roy Radakovich

Michael Paul Madden

Lauren Long

Andrew J Custer

Francisco Gomez Ruiz

David Sarment

Dimitrije Dinic

Andrew Custer

James Bertolina

Russell Jahnke

William Roberts

Charles Cain

Michael Thomas Kusner

A histotripsy therapy system configured for the treatment of tissue is provided, which may include any number of features. Provided herein are systems and methods that provide efficacious non-invasive and minimally invasive therapeutic, diagnostic and research procedures. In particular, provided herein are optimized systems and methods that provide targeted, efficacious histotripsy in a variety of different regions and under a variety of different conditions without causing undesired tissue damage to intervening/non-target tissues or structures.

Histotripsy systems and methods

An imaging system includes components to allow the system to be compact, highly transportable, and capture images in non-conventional settings. An imaging device includes an exoskeleton configured to house and provide structural support for an x-ray source and a detector and a spindle structure protruding from an outer surface of the exoskeleton. The imaging device also includes an x-ray source and a detector affixed to an internal surface of the exoskeleton and a rotation motor configured to rotate the exoskeleton about the spindle structure.

Compact imaging device and system

A wireless network system for providing reliable transmission over a wireless network includes a multicast stream source including a modifier and a plurality of multicast stream recipients in communication with the multicast stream source with each of the plurality of multicast stream recipients including an outgoing library.

Systems and methods for providing reliable multicast transmissions to multiple stream recipients over a wireless network

A safety network controller is comprised in an electronic safety system. The safety network controller comprises a first serial port and a second serial port, each of which is configured to communicatively connect to a redundant safety network controller via a respective daisy chain network. Each daisy chain network comprises at least one safety device controller that is controlling a corresponding safety device. The safety network controller further comprises network circuitry configured to communicatively connect to the redundant safety network controller via a packet-switched network. The safety network controller further comprises processing circuitry configured to exchange, with the redundant safety network controller: serial communication via each of the daisy chain networks; packets via the packet-switched network; and responsibility for control over one or more of the safety device controllers in response to detecting a failure.

Safety network controller redundancy in an electronic safety system

Methods and devices for manipulating an articulating arm of an ultrasound therapy system are provided. In one embodiment an articulating arm comprises a first articulating arm link, a second articulating arm link, a rotating joint configured to rotationally connect the first articulating arm link to the second articulating arm link so that the first and second articulating arm links are substantially perpendicular, and an arm limiter attached to the second articulating arm link, the arm limiter being configured to limit rotation of the second articulating arm link along the rotating joint with respect to the first articulating arm link. An ultrasound therapy transducer and imaging system can be mounted on the articulating arm. Methods for performing manipulating the arm and system are also provided.

Articulating arm limiter for cavitational ultrasound therapy system

A computed tomography system is disclosed with a gantry assembly and a base assembly. The gantry assembly having a x-ray source, and a x-ray imager. The base assembly is configured to receive power and provide mechanical stability. A connection interface is located between the gantry assembly and the base assembly. The connection interface is configured to mechanically lock the gantry assembly to the base assembly and provide power to the gantry assembly through the base assembly.

Modular and configurable computed tomography scanning assembly

A method for maintaining possession of a firearm includes the steps of transmitting a signal between a first transceiver coupled to a firearm and a second transceiver of a secondary carry implement. The secondary carry implement has an alert component. The alert component is activated when a predetermined proximity between the firearm and the secondary carry component is exceeded. The predetermined proximity is inferred from signal strength from the first transceiver that is detected by the second transceiver.

Gun proximity electronic tether and alert

Methods and devices for producing cavitation in tissue are provided. In one embodiment, a shock scattering method of Histotripsy therapy comprises delivering an initiation pressure waveform from an ultrasound therapy transducer into tissue, the initiation pressure waveform being configured to produce at least one bubble in the tissue, delivering a scattering pressure waveform from the ultrasound therapy transducer into the at least one bubble within a life-cycle of the at least one bubble, and producing cavitation nuclei near the at least one bubble with the scattering pressure waveform. The scattering pressure waveform can be delivered during the life-cycle of the at least one bubble. In some embodiments, the scattering pressure waveform is delivered within 5 &#x3bc;s to 1 s of the initiation pressure waveform. Systems for performing shock scattering Histotripsy therapy are also discussed.

Histotripsy excitation sequences optimized for bubble cloud formation using shock scattering

A medical imaging and therapy device is provided that may include any of a number of features. One feature of the device is that it can image a target tissue volume and apply ultrasound energy to the target tissue volume. In some embodiments, the medical imaging and therapy device is configured controllably apply ultrasound energy into the prostate by maintaining a cavitational bubble cloud generated by an ultrasound therapy system within an image of the prostate generated by an imaging system. The medical imaging and therapy device can be used in therapeutic applications such as Histotripsy, Lithotripsy, and HIFU, for example. Methods associated with use of the medical imaging and therapy device are also covered.

Automated control of micromanipulator arm for histotripsy prostate therapy while imaging via ultrasound transducers in real time

A medical imaging and therapy device is provided that may include any of a number of features. One feature of the device is that it can acoustically couple an ultrasound therapy transducer to a patient. In some embodiments, the medical imaging and therapy device is configured to conform to the anatomy of a patient's perineal area to acoustically couple an ultrasound therapy transducer to the patient for treatment of BPH. The medical imaging and therapy device can be used in therapeutic applications such as Histotripsy, Lithotripsy, and HIFU, for example. Methods associated with use of the medical imaging and therapy device are also covered.

Disposable acoustic coupling medium container

Growing community of inventors

Ann Arbor, MI, United States of America

Dejan Teofilovic