Other

Warsaw Orthopedic, Inc.

Stryker Technologies Corporation

Howmedica Osteonics Corporation

Johnson & Johnson Gmbh

Howmedica Corp.

Johnson & Johnson Products, Inc.

Johnson & Johnson Orthopaedics, Inc.

Johnson & Johnson Orthopaedics, Inc. G35

Stryker Instruments

Deger C Tunc

Bruce D Henniges

Todd M Boyce

David R Kaes

John Winterbottom

David Knaack

Mark A Wasserman

Subhabrata Bhattacharyya

James L Russell

Douglas L Tyler

Chitranjan S Ranawat

Peter Forst

Richard D Scott

Amar S Ranawat

Paul T Longo

Jon J Ahola

Robert F Landeryou

Gregory D Diamond

Mark Thomas Salzberger

An osteoimplant composite comprising a plurality of particles of an inorganic material, a bone substitute material, a bone-derived material, or any combination thereof; and a polymer material with which the particles are combined. The composite is either naturally moldable or flowable, or it can be made moldable or settable. After implantation, the composite may be set to provide mechanical strength to the implant. The inventive composite have the advantage of being able to fill irregularly shape implantation site while at the same time being settable to provide the mechanical strength required for most orthopedic applications. The invention also provides methods of using and preparing the moldable and flowable composites.

Injectable and moldable bone substitute materials

A device for releasing a therapeutic agent in the body space in the form of a prosthetic joint implant having a first portion such as a stemmed portion for contacting bone tissue in an intramedullary canal of a long bone. The implant has a second portion which extends into the body space such as a joint space. The joint component contains a reservoir filled with a bioabsorbable/resorbable polymer which includes a therapeutic agent. The reservoir is open or in contact with the joint space as the body fluid diffuses in and out of the polymeric device it carries the drug into the joint space.

Prosthesis with sustained release analgesic

A process for forming a rod of bioabsorbable polymeric material includes extruding the material at a temperature above its melting point at a controlled rate of between 0.4 to 20 feet per minute to form a continuous rod. The continuous rod is then cooled by passing the rod through a cooling bath to cause nucleation. The continuous rod is passed through a first puller running at least at the same speed as the extruder. A second puller is provided which is moving faster than the first puller so that the continuous rod is elongated at a ratio of between 2 and 12 times. During this elongation, the rod is heated to a temperature of between 55&#xb0; C. and 140&#xb0; C. in an oven located between the first and second pullers. The rod is annealed at a temperature of between 70&#xb0; C. and 110&#xb0; C. after being elongated but prior to exiting the second puller. Upon exiting the second puller, the tension in the rod is released and the continuous rod is then allowed to cool. A cutting station is then provided to cut the continuous rod into desired lengths.

Process for forming bioabsorbable implants

A process for forming a rod of bioabsorbable polymeric material includes extruding the material at a temperature above its melting point at a controlled rate of between 0.4 to 20 feet per minute to form a continuous rod. The continuous rod is then cooled by passing the rod through a cooling bath to cause nucleation. The continuous rod is passed through a first puller running at least at the same speed as the extruder. A second puller is provided which is moving faster than the first puller so that the continuous rod is elongated at a ratio of between 2 and 12 times. During this elongation, the rod is heated to a temperature of between 55&deg; C. and 140&deg; C. in an oven located between the first and second pullers. The rod is annealed at a temperature of between 70&deg; C. and 110&deg; C. after being elongated but prior to exiting the second puller. Upon exiting the second puller, the tension in the rod is released and the continuous rod is then allowed to cool. A cutting station is then provided to cut the continuous rod into desired lengths.

A bioabsorbable material such as a terpolymer of poly-(L-lactide/D-lactide/glycolide). The material may consist of 85 molar percent L-lactide, 5 molar percent D-lactide, and 10 molar percent glycolide. The material may have a heat of fusion of about 15-25 J/G, tensile strength retention at 26 weeks of incubation of at least about 50%, and tensile strength retention at 52 weeks of incubation of at most about 25%. The material may be used in implantable devices such as bone fixation devices.

Bioabsorbable materials and medical devices made therefrom

A method for reducing residual ethylene oxide levels in sterilized goods by reacting the residual ethylene oxide with water after the sterilization reaction is completed, thus converting some of the ethylene oxide into ethylene glycol according to the formula (I):

Special cycle for ethylene oxide sterilization

Processes are set forth for forming high strength thermoplastic polymer bone fixation devices used, for example, in orthopedic surgery, where 'strength' is quantified in terms of a given device's pullout strength, tensile modulus, shear strength and breaking torque strength. Products of the aforementioned process are contemplated by the invention as well, with both 'bioabsorbable' devices, for example, screws which are absorbable in an animal body and do not need to be removed after the bone in which they are inserted has healed; and non-bioabsorbable devices being described.

High strength internal bone fixation devices and process for forming same

Processes are set forth for forming high strength thermoplastic polymer bone fixation devices used, for example, in orthopedic surgery, where 'strength' is quantified in terms a given device's pullout strength, tensile modulus, shear strength and breaking torque strength. Products of the aforementioned process are contemplated by the invention as well, with both 'bioabsorbable' devices, for example, screws which are absorbable in an animal body and do not need to be removed after the bone in which they are inserted has healed; and non-bioabsorbable devices being described.

Process for forming high strength internal bone fixation devices

A process of purifying and stabilizing a high molecular weight polylactide polymer by contacting solid polymer particles with methyl alcohol and subsequently acetone.

Process of preparing an absorbable polymer

An anti-displacement device and method are disclosed for implantation of a prosthetic bone joint in a bone. A biodegradable biocompatable anti-displacement device comprising a biodegradable biocompatible polymer is directed through an orifice, defined by a cup of a prosthetic bone joint, and into interfering contact with bone tissue of the bone. Displacement of the cup is thereby sufficiently limited to allow bone tissue growth at the cup to fix the prosthetic bone joint to the bone while body fluid at the bone tissue and contacting the elongate member biodegrades the elongate member.

Biodegradable biocompatible anti-displacement device for prosthetic bone

An absorbable bone plate resistant to breakage fabricated with such interrelated dimensions that the highest stresses developed along the length of the plate when the plate is implanted are relatively constant and do not vary by more than 20% and preferably do not vary by more than 10%.

Absorbable bone plate

Disclosed are method and composition for periodically coating the internal, food absorbing surface of the small intestine of a mammal by ingesting said composition which is capable of forming at least a partial nutrient barrier on said intestine.

Growing community of inventors

East Brunswick, NJ, United States of America

Deger C Tunc