The J. David Gladstone Institutes

The J. David Gladstone Institutes, a Testamentary Trust Established Under the Will of J. David Gladstone

University of California

Deepak Srivastava

Masaki Ieda

Kimberly R Cordes

Tamer M A Mohamed

Jidong Fu

Christina Theodoris

Tamer MA Mohamed

The present disclosure provides methods for inducing cell cycle reentry of postmitotic cell. The present disclosure further provides cells and compositions for treating diseases, such as cardiovascular diseases, neural disorders, hearing loss, and diabetes.

Methods for inducing cell division of postmitotic cells

The present disclosure provides method of generating cardiomyocytes from post-natal fibroblasts. The present disclosure further provides cells and compositions for use in generating cardiomyocytes.

Methods for generating cardiomyocytes

The present disclosure provides methods of inducing smooth muscle cell differentiation. The present disclosure provides genetically modified cells comprising exogenous miR-143 and/or miR-145 nucleic acids; and artificial tissues comprising the genetically modified cells. The present disclosure provides methods and compositions for reducing pathological angiogenesis. The present disclosure provides methods of inducing therapeutic angiogenesis. The present disclosure provides methods, compositions, and devices for inhibiting vascular smooth muscle cell proliferation.

Methods of modulating smooth muscle cell proliferation and differentiation

Growing community of inventors

San Francisco, CA, United States of America

Deepak Srivastava