Varian Medical Systems, Inc.

Varian Medical Systems International Ag

Siemens Healthineers International Ag

Varian Medical Systems Particle Therapy Gmbh

Varian Medical Systems Particle Therapy Gmbh & Co Kg

Deepak Khuntia

Eric Abel

Christel Smith

Anthony Magliari

Timo K Koponen

Edward Joseph Vertatschitsch

Michael Matthew Folkerts

Reynald Vanderstraeten

Jessica Perez

Josh Star-Lack

Corey Zankowski

Wolfgang Kaissl

Camille Noel

Stanley Mansfield

Renate Parry

Jan Timmer

Patrick Kupelian

Swati Girdhani

Jan H Timmer

Timo Koponen

Jan Hein Timmer

A computing system comprising a central processing unit (CPU), and memory coupled to the CPU and having stored therein instructions that, when executed by the computing system, cause the computing system to execute operations to generate a radiation treatment plan. The operations include accessing a minimum prescribed dose to be delivered into and across the target, determining a number of beams and directions of the beams, and determining a beam energy for each of the beams, wherein the number of beams, the directions of the beams, and the beam energy for each of the beams are determined such that the entire target receives the minimum prescribed dose. The operations further include prescribing a dose rate and optimizing dose rate constraints for FLASH therapy, and displaying a dose rate map of the FLASH therapy.

Flash therapy treatment planning and oncology information system having dose rate prescription and dose rate mapping

A dose rate-volume histogram can be generated for a target volume. The dose rate-volume histogram can be stored in computer system memory and used to generate a radiation treatment plan. The radiation treatment plan can be used as the basis for treating a patient using a radiation treatment system.

Radiation treatment based on dose rate

In various embodiments, a radiation therapy method can include loading a planning image of a target in a human. In addition, the position of the target can be monitored. A computation can be made of an occurrence of substantial alignment between the position of the target and the target of the planning image. Furthermore, after the computing, a beam of radiation is triggered to deliver a dosage to the target in a short period of time (e.g., less than a second).

Triggered treatment systems and methods

Methods for treating tumors by administering FLASH radiation and a therapeutic agent to a patient with cancer are disclosed. The methods provide the dual benefits of anti-tumor efficacy plus normal tissue protection when combining therapeutic agents with FLASH radiation to treat cancer patients. The methods described herein also allow for the classification of patients into groups for receiving optimized radiation treatment in combination with a therapeutic agent based on patient-specific biomarker signatures. Also provided are radiation treatment planning methods and systems incorporating FLASH radiation and therapeutic agents.

Methods of use of ultra-high dose rate radiation and therapeutic agent

A dose rate-volume histogram is generated for a target volume. The dose rate-volume histogram can be stored in computer system memory and used to generate a radiation treatment plan. An irradiation time-volume histogram can also be generated for the target volume. The irradiation time-volume histogram can be stored in computer system memory and used to generate the radiation treatment plan.

Radiation treatment planning based on dose rate

Growing community of inventors

Los Altos, CA, United States of America

Deepak Khuntia