Prokidney

Tengion, Inc.

Inregen

Regenmedtx, LLC

Regenmed (cayman) Ltd.

Regenmed, Inc.

Deepak Jain

Jeffrey Eldon Fish

Richard Payne

Manuel J Jayo

John W Ludlow

Timothy A Bertram

Oluwatoyin A Knight

Namrata D Sangha

Joydeep Basu

Roger M Ilagan

Andrew T Bruce

Kelly Guthrie

Darell McCoy

Christopher W Genheimer

Craig R Halberstadt

Sharon C Presnell

Russell W Kelley

Shay M Wallace

Eric S Werdin

Sumana Choudhury

Neil F Robins

Bryan R Cox

Elias A Rivera

Thomas Spencer

Benjamin Watts

H Scott Rapoport

Kelly I Guthrie

Sarah F Quinlan

Neil F Robbins

Monica A Serban

Sarah A Boyd

Neil Robbins

I Guthrie; Kelly

Sangha Namtata

Darrell Mccoy

Wendy Sharp

Dominic M Justewicz

Jacob E Shokes

Teresa B Burnette

Darell Mccoy

Provided herein are, inter alia, extracellular products (e.g., vesicles such as microvesicles, e.g., exosomes) produced by renal cells (such as bioactive renal cells, e.g., selected renal cells). Methods of altering components (such as miRNAs or proteins) of vesicles produced by cells, as well as methods of producing vesicles comprising various compounds are also included. Also provided are diagnostic and treatment methods.

Compositions comprising cell-delivered vesicles and uses thereof

The present invention concerns methods of using bioactive renal cell populations to provide regenerative effects to a native kidney for the treatment of chronic kidney disease.

Bioactive renal cells for the treatment of chronic kidney disease

The present invention concerns bioactive renal cell populations, renal cell constructs, and methods of making and using the same.

Bioactive renal cells

The present invention concerns bioactive renal cells populations, renal cell constructs, and methods of making and using the same.

The present invention concerns phase changing injectable formulations for organ augmentation containing active agents, such as bioactive cell populations, and methods of making and using the same.

Injectable formulations for organ augmentation

The present invention relates to the regeneration, reconstruction, repair, augmentation or replacement of organs or tissue structures using scaffolds and autologous cells that are not derived from such organs or tissues.

Cell scaffold constructs

Biocompatible synthetic or natural scaffolds are provided for the reconstruction, repair, augmentation or replacement of organs or tissue structures in a patient in need of such treatment. The scaffolds are shaped to conform to at least a part of the organ or tissue structure and may be seeded with one or more cell populations. Inserts, receptacles and ports are also provided for the attachment of tubular vessels to the neo-organ scaffolds. The seeded scaffolds are implanted into the patient at the site in need of treatment to form an organized organ or tissue structure. The scaffolds may be used to form organs or tissues, such as bladders, urethras, valves, and blood vessels.

Scaffolds for organ reconstruction and augmentation

Cell-scaffold constructs

Growing community of inventors

Winston-Salem, NC, United States of America

Deepak Jain