National Starch and Chemical Investment Holding Corporation

Deepak Hariharan

Rama S Chandran

Pravin K Kukkala

Roman Bradel

A graft copolymer for use as an adhesive for drug delivery patches or dressings that is resistant to dissolution in the presence of skin penetration enhancers comprises copolymerized acrylic and, optionally, vinyl monomers, to form a backbone polymer, to which are grafted polymeric moieties that do not absorb greater than 3% by weight of a skin-penetration enhancer under thermodynamic equilibrium at 25.degree. C. if independently introduced into an excess of the enhancer. Preferably, the grafted polymers are selected from the classes of polybutylene, polysaccharide, poly(ethyleneoxide/propyleneoxide), and polyamide polymers, and specific grafted polymers will depend on the specific enhancers used in a particular drug delivery system.

Adhesives resistant to skin-penetration enhancers

An adhesive composition comprising: a) a metal-chelate cross-linker; b) a polyurethane or diepoxy cross-linker; c) an acrylate base polymer; d) a stabilizer for the metal-chelate cross-linker; and e) a non-reactive organic solvent is provided. The adhesive composition is stable and high-performance. The stable adhesive composition is stored as a one-part system.

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Somerville, NJ, United States of America

Deepak Hariharan