Visolis, Inc.

Massachusetts Institute of Technology

Deepak Dugar

Brian Neltner

Gregory N Stephanopoulos

Marjan De Mey

Jose Luis Avalos

Brian Pereira

Tobias Friedberger

Formulations containing biologically-produced, high-purity R-mevalonolactone are provided for modulating the expression of genes and metabolism related to epidermal turnover, hyaluronic acid synthesis, barrier function, anti-aging elasticity, extracellular matrix degradation, inflammation, stress, and pigmentation in human skin. The biologically-produced, high-purity R-mevalonolactone may be used as an ingredient in pharmaceutical, food, or cosmetic products and may be applied topically or ingested for modulation of gene expression and metabolism.

Highly sustainable compositions for modulation of gene expression in human skin, and methods of production thereof

A process is provided for converting mevalonic acid into various useful products and derivatives. More particularly, the process comprises reacting mevalonic acid, or a solution comprising mevalonic acid, in the presence of a solid catalyst at an elevated temperature and pressure to thereby form various biobased products. The process may also comprise: (a) providing a microbial organism that expresses a biosynthetic mevalonic acid pathway; (b) growing the microbial organism in fermentation medium comprising suitable carbon substrates, whereby biobased mevalonic acid is produced; and (c) reacting the biobased mevalonic acid in the presence of a solid catalyst at an elevated temperature and pressure to yield various biobased products.

Processes for conversion of biologically derived mevalonic acid

The invention relates to recombinant cells and their use in the production of ethylene glycol.

Engineering microbes and metabolic pathways for the production of ethylene glycol

Growing community of inventors

Berkley, CA, United States of America

Deepak Dugar