Msd Wellcome Trust Hilleman Laboratories Pvt. Ltd.

Mds Wellcome Trust Hilleman Laboratories Pvt. Ltd.

Deepa Sikriwal

Davinder Gill

Tarun Sharma

Nidhi Shukla

Robert B Evans

Sachin Kale

Neeraj Joshi

Vibhu Kanchan

Madhu Madan

Nitin Saigal

The present invention relates to a novel process of production of purified recombinant cholera toxin B (rCTB) which provides protection against diarrhea caused by various bacteria such asand Enterotoxigenic(ETEC). More particularly, the present invention relates to a process of production of rCTB with significantly higher yield and higher purity. The present invention also relates to a vaccine formulation having synergistic protection againstand cross protection against ETEC.

Process for production of purified recombinant cholera toxin B (rCTB) and formulation thereon

The present invention relates to an improved thermostable spray dried rotavirus vaccine formulation and the process of preparing the same. More specifically the present invention discloses thermostable liquid, powder or granule-based rotavirus vaccine prepared using the spray drying process, such that the said vaccine has improved heat-stability, ease-of-use, ease-of-transportation and affordability features with significantly better chance of being adopted in developing and low income country's vaccination program.

Thermostable spray dried rotavirus vaccine formulation and process thereof

The present invention relates to a thermostable freeze dried rotavirus vaccine formulation and the process of preparing the same. More specifically the present invention discloses multivalent thermostable liquid, powder or cake based rotavirus vaccine formulation prepared using the freeze drying process, such that the said vaccine formulation possess improved heat-stability, easy to use and transport and highly affordable thereby meeting the requirements of developing and low income country's vaccination program. The said freeze dried rotavirus vaccine formulation along with reconstitution buffer is so engineered to be suitable for filling in appropriate packaging containers/ closures so designed such that they reduce the logistics requirement for storage.

Thermostable freeze dried rotavirus vaccine formulation and process to prepare thereof

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New Delhi, India

Deepa Sikriwal