Norton (waterford) Limited

Ivax Pharmaceuticals Ireland

Teva Pharmaceuticals Ireland

Teva Branded Pharmaceutical Products R&d, Inc.

Teva Pharmecuticals Ireland

Ivax Pharmaeuticals Ireland

Norton Gmbh

Teva Parmaceuticals Ireland

Declan Walsh

Daniel R Buck

Derek Fenlon

Simon Kaar

Jeffrey A Karg

Robert Charles Uschold

Jan Geert Hazenberg

Paul Clancy

Paul Prendergast

Dan Buck

Fenlon Derek

Trevor Kent

Niall Thompson

Xian-Ming Zeng

Jade Ching-Ying Ly

Armando Morales

Simon G Kaar

Jade Ly

Dan Knockane Buck

An inhaler housing () for an inhaler () for inhaling inhalable substances, the inhaler having: a body () and a dose counter () with a return spring (), wherein a distinct guide surface () is provided for guiding the end of the return spring into a recess (), the distinct guide surface being wider than an entrance mouth () of the recess, a dose counter chamber () being provided which is separated from a tubular interior space () of the inhaler by a barrier (), the barrier including a stepped upper wall area () including at least three steps () at different levels, the inhaler having a valve stem block () having an inner bore and a valve stem block having a seal () in the inner bore with a second diameter which is smaller than a first diameter of the inner bore, the inhaler having a canister () being adapted to move during operation between 1 and 4 mm, a drive being arranged to apply a firing force of between 15N and 60N of force to the canister at a position of the canister relative to a valve stem () at which the canister fires.

Inhalers and related methods

A breath actuated metered dose inhaler may comprise a canister fire system configured to fire a medicament containing canister in response to patient inhalation. The canister fire system may comprise a pneumatic force holding unit and having a rest configuration in which a metering valve of the canister is in a refill configuration; a prepared configuration in which a canister actuation force is retained by the pneumatic force holding unit and the canister fire system is actuatable by patient inhalation induced airflow; and a fire configuration in which the metering valve is in a dose delivery position. When in the prepared configuration, the force retained by the pneumatic force holding unit may be reduced by less than about 6% over a period of 5 minutes, preferably less than about 3% over a period of 5 minutes.

Breath actuated inhaler

An inhaler () has a main body for accommodating a medicament reservoir (), a canister fire system for moving a canister () to release a dose in response to air flow, a cap housing () for enclosing the canister fire system and canister within an interior chamber defined by the main body () and a cap housing, wherein a lock system () is provided for locking the cap housing on the main body.

A nasal inhaler for the inhalation of inhalable substances comprise: a canister having an interior reservoir containing pressurised inhalable substances including fluid; a metering valve including a metering chamber and a valve stem defining a communication path between the metering chamber and the interior reservoir, the communication path including an opening configured to permit flow between a transfer space inside the valve stem and the interior reservoir, the interior reservoir being arranged for orientation above the metering chamber whereby gas located within the metering chamber is replaced with liquid from the interior reservoir.

An inhaler () for the inhalation of inhalable substances comprise: a canister () having an interior reservoir () containing pressurised inhalable substances including fluid; a metering valve () including a metering chamber () and a valve stem () defining a communication path between the metering chamber and the interior reservoir, the communication path () including an opening () configured to permit flow between a transfer space inside the valve stem and the interior reservoir, the interior reservoir being arranged for orientation above the metering chamber whereby gas such as air located within the metering chamber is replaced with liquid from the interior reservoir.

An inhaler includes a main body having a canister housing, a medicament canister retained in a central outlet port of the canister housing, and a dose counter having an actuation member for operation by movement of the medicament canister. The canister housing has an inner wall, and a first inner wall canister support formation extending inwardly from a main surface of the inner wall. The canister housing has a longitudinal axis X which passes through the center of the central outlet port. The first inner wall canister support formation, the actuation member, and the central outlet port lie in a common plane coincident with the longitudinal axis X such that the first inner wall canister support formation protects against unwanted actuation of the dose counter by reducing rocking of the medicament canister relative to the main body of the inhaler.

Dose counter for inhaler having an anti-reverse rotation actuator

An inhaler housing () for an inhaler () for inhaling inhalable substances, the inhaler having: a body () and a dose counter () with a return spring (), wherein a distinct guide surface () is provided for guiding the end of the return spring into a recess (), the distinct guide surface being wider than an entrance mouth () of the recess, a dose counter chamber () being provided which is separated from a tubular interior space () of the inhaler by a barrier (), the barrier including a stepped upper wall area () including at least three steps () at different levels, the inhaler having a valve stem block () having an inner bore and a valve stem block having a seal () in the inner bore with a second diameter which is smaller than a first diameter of the inner bore, the inhaler having a canister () being adapted to move during operation between 1 and 4 mm, a drive being arranged to apply a firing force of between 15 N and 60 N of force to the canister at a position of the canister relative to a valve stem () at which the canister fires.

A breath actuated metered dose inhaler may include a canister fire system configured to fire a medicament containing canister in response to patient inhalation. The canister fire system may include a pneumatic force holding unit and having a rest configuration in which a metering valve of the canister is in a refill configuration; a prepared configuration in which a canister actuation force is retained by the pneumatic force holding unit and the canister fire system is actuatable by patient inhalation induced airflow; and a fire configuration in which the metering valve is in a dose delivery position. When in the prepared configuration, the force retained by the so pneumatic force holding unit may be reduced by less than about 6% over a period of 5 minutes, preferably less than about 3% over a period of 5 minutes.

A dose counter for an inhaler includes a counter display arranged to indicate dosage information, and a drive system arranged to move the counter display incrementally in a first direction from a first station to a second station in response to actuation input. A regulator is provided which is arranged to act upon the counter display at the first station to regulate motion of the counter display at the first station to incremental movements.

A method of manufacturing a series of incremental dose counters for inhalers, which includes manufacturing the dose counters with nominal canister fire and dose count positions of a dose counter actuator relative to a dose counter chassis or inhaler main body, and which includes building the dose counters with an average dose count position in the series being, in canister fire process, at or after an average canister fire position in the series.

Dose counters for inhalers, inhalers and methods of assembly thereof

A nasal spray device for the delivery of a pharmaceutical formulation to the nasal cavity in metered doses. The device includes: a pressurised aerosol canister including a vial containing a pharmaceutical formulation including an active ingredient, a propellant and, optionally, a co-solvent, the aerosol canister further including a metering valve having a valve stem; and an actuator for the aerosol canister, the actuator including a stem block having a receptacle into which the valve stem of metering valve of the aerosol canister is received and axially located and being displaceable relative to the vial of the aerosol canister to actuate the metering valve of the aerosol canister, a sump extending below the receptacle, the stem block further defining a discharge orifice for the pharmaceutical formulation and a transfer channel through which a dispensed dose of the pharmaceutical formulation is able to pass from the sump to the discharge orifice.

Nasal spray device

An incremental dose counter for a metered dose inhaler having a body arranged to retain a canister for movement of the canister relative thereto, the incremental dose counter having a main body, an actuator arranged to be driven and to drive an incremental output member in a count direction in response to canister motion, the actuator being configured to restrict motion of the output member in a direction opposite to the count direction.

Growing community of inventors

Co. Kilkenny, Ireland

Declan Walsh