University College Cork

Declan Soden

Morgan O'Brien

Patrick Forde

Gerald Christopher O'Sullivan

Peter McGeehin

Anthony Morrissey

Denton A M Prior

Andrew Watson

Christopher Collins

Colum Dunne

John Hinchion

John Piggott

John 236 The Sweepstakes Piggott

Colum 23 Richview Dunne

Gerald"Cuan Baoi" O'SULLIVAN

Denton The Cottage Prior

The present invention relates to a method for the treatment of cancer in a subject which comprises the steps of: (i) administering electroporation to a tumour in the subject; and (II) administering a T or B-cell activiating agent to the subject, wherein step (i) and (II) may be performed in either order.

Method for treating cancer

The present invention relates to a method for the treatment of cancer in a subject which comprises the steps of: (i) administering electroporation to a tumour in the subject; and (ii) administering a T or B-cell activating agent to the subject, wherein step (i) and (ii) may be performed in either order.

A thoracoscopic electroporation device for carrying out electroporation on tissue includes a suction head and a plurality of needle electrodes. The needle electrodes include a central needle providing a first electrode and a plurality of second needles which are spaced-apart around the periphery of the suction head. The electrodes are movable from a retracted configuration to a deployed configuration and in the deployed configuration the needles extend from the suction head. The suction head has a retracted delivery configuration and an expanded deployed configuration. The suction head includes a suitable flexible material for biasing the suction head into the expanded deployed configuration. The suction head has channels for the needles and the needles are movable through the channels from the retracted to the deployed configuration. In the deployed configuration, the central first needle extends beyond the peripheral needles.

Thoracoscopic electroporation device with a suction head and with needle electrodes

An apparatus for use in carrying out a prophylactic or treatment procedure on tissue comprises a head piecehaving a receiverfor receiving an instrument such as an endoscopeand chamberinto which tissue is drawn by vacuum. There are two electrodeswithin the chamberand two electrodeslocated on opposite sides of the entranceinto the chamber. The voltage applied to the inner and outer electrodescan be varied independently an allows tissue underlying the device to be treated. This is particularly important for colorectal cancers.

Device for treating tissue

Apparatus () for carrying out a prophylactic or treatment procedure on tissue comprises a device () having a chamber () and at least one active element such as an electrode () within the chamber (). The chamber () has an opening () through which tissue is drawn into the chamber (). Means for drawing the tissue into the chamber may comprise a vacuum lumen with vacuum orifices () in the chamber (). Treatment such as electroporation may be applied to tissue in the chamber ().

Apparatus for use in the prophylaxis or treatment of tissue

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Cork, Ireland

Declan Soden