Enzon Pharmaceuticals, Inc.

Shenzhen Enduring Biotech, Ltd.

Ethicon, Gmbh

Belrose Pharma, Inc.

Dechun Wu

Richard B Greenwald

Hong Zhao

Puja Sapra

Maria Belen Rubio

Shu-min Liu

Susan L Adler, Legal Representative

Yuxin Han

Yuewu Chen

This invention relates to multi-specific molecules, such as long acting multi-specific antibodies. Also disclosed are related methods.

Long acting multi-specific molecules and related methods

A novel in vitro system and method for predicting the in vivo behavior, such as absorption time or mechanical strength retention, of biodegradable polymeric implants and medical devices. Data from this in vitro method are correlated to in vivo absorption data, allowing for the prediction of accurate in vivo behaviors, such as absorption times. The system uses a novel bypass loop to maintain the integrity of pH measuring devices to improve the reproducibility of data collected during in vitro testing.

Accelerated hydrolysis system

This invention relates to multi-specific molecules, such as long acting multi-specific antibodies. Also disclosed are relates methods.

A four arm-polyethylene glycol-7-ethyl-10-hydroxycamptothecin conjugate, such as, is disclosed. Methods of making the conjugates and methods of treating mammals using the same are also disclosed.

Multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamptothecin for treatment of breast, colorectal, pancreatic, ovarian and lung cancers

Methods for preparing substantially non-antigenic polymers having lone electron pair-containing moieties in high purity are disclosed. The polymers are useful as intermediates for synthesis of amine-based polymers and in the formation of activated polymers for conjugation with nucleophiles. Conjugates and methods of preparation and treatment with the conjugates are also disclosed. The resultant polymer-amines are of sufficient purity so that expensive and time consuming purification steps required for pharmaceutical grade polymers are avoided.

Methods of preparing activated polymers having alpha nitrogen groups

A process for efficiently preparing polymer conjugates such as branched PEG-polypeptide conjugates, in large scale without column chromatography clean up of the activated PEG linkers to remove impurities is disclosed.

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Bridgewater, NJ, United States of America

Dechun Wu