The University of British Columbia

Centre for Drug Research and Development

Methylation Sciences International Srl

Angiotech International Ag

Msi-195 Holdings, LLC

Dechi Guan

Richard Tom Liggins

Martin E Gleave

Rajesh Kumar Kainthan

Donald Elliott Brooks

Jayachandran N Kizhakkedathu

John K Jackson

Helen M Burt

Clement Mugabe

Alan So

Lu Ye

I David MacDonald

William L Hunter

David M Gravett

Philip Michael Toleikis

Rui Avelar

Arpita Maiti

Pierre E Signore

David I Macdonald

Provided herein are compositions and formulations comprising S-adenosyl-L-methionine ('SAM-e' or “SAMe”) and one or more gallic acid esters. Also provided herein are methods for improving the delivery of SAMe. Compositions and formulations provided herein increase SAMe plasma concentrations and area under the curve (AUC) values. Also provided herein are methods of treating a disease or disorder in a subject by administering compositions or formulations comprising exogenous SAMe and one or more gallic acid esters.

Compositions comprising S-adenosylmethionine and a gallic acid ester

Herein are provided derivatized hyperbranched polyglycerols ('dHPGs'). The dHPG comprises a core comprising a hyperbranched polyglycerol derivatized with CCalkyl chains and a shell comprising at least one hydrophilic substituent bound to hydroxyl groups of the core, wherein the hyperbranched polyglycerol comprises from about 1 to about 200 moles of the at least one hydrophilic substituent. The dHPGs are for use as agents for the delivery of a drug or other biologically active moiety to the urinary tract, the digestive tract, the airways, the vaginal cavity and cervix and the peritoneal cavity to treat indications such as cancer, which may be useful in the treatment of or the manufacture of a medicament, in the preparation, of a pharmaceutical composition for the treatment of cancer, as a pre-treatment or co-treatment to improve drug uptake in a tissue. Furthermore, there are provided methods of making dHPGs.

Derivatized hyperbranched polyglycerols

Provided herein are compositions and formulations comprising S-adenosyl-L-methionine ('SAM-e' or 'SAMe') and one or more gallic acid esters. Also provided herein are methods for improving the delivery of SAMe. Compositions and formulations provided herein increase SAMe plasma concentrations and area under the curve (AUC) values. Also provided herein are methods of treating a disease or disorder in a subject by administering compositions or formulations comprising exogenous SAMe and one or more gallic acid esters.

Agents, compositions, and implants are provided herein for treating diverticular disease (e.g., diverticulosis and diverticulitis). In particular, fibrosis-inducing agents, hemostatic agents, and/or anti-infective agents, or compositions containing one or more of these agents are provided for use in methods for treating diverticular disease.

Compositions and methods for treating diverticular disease

Implants are used in combination with a fibrosis-inducing agent in order to induce fibrosis that may otherwise not occur when the implant is placed within an animal or increase fibrosis between the implant and the host tissue.

Medical implants and fibrosis-inducing agents

Growing community of inventors

Vancouver, Canada

Dechi Guan