Ethicon, Gmbh

Johnson & Johnson Medical Gmbh

Debra Timm

Henry K Hui

Szu-Min Lin

Anthony Lemus

Ben Fryer

Syed F Hossainy

Mark B Roller

Mora Carolynne Melican

Tralance O Addy

Leslie A Feldman

Su Syin Wu

Sam Nutt

Ron Albers

Hung P Nguyen

A sterilization process challenge device has a sterilization indicator contained within a container; and a variable diffusion restriction into said container.

Variable resistance sterilization process challenge device and method

The invention provides a method for single-step surface modification, grafting and sterilization for bio-active coating on materials and biomaterials used in medical devices, such as catheters, tissue engineering scaffolds, or drug delivery carrier materials. This may include any medical device or implantable that could benefit from improved antithrombogenic and biocompatible surfaces. Other relevant device examples may include heparin or urokinase coated stents to reduce clotting and restenosis, dental or ophthamological implants. These materials may be comprised of a variety of polymeric compositions such as, polyurethane, polyester, polytetrafluoroethylene, polyethylene, polymethylmethacrylate, polyHEMA, polyvinyl alcohol, polysiloxanes, polylactic or glycolic acids, polycaprolactone, etc. The substrates can also be metal, ceramics or biologically derived materials.

Sterilization of bioactive coatings

A packaging enclosure for receiving a flexible endoscope during a sterilization procedure and sterile storage thereafter has a portion thereof which is semi-permeable. Provision is made for hanging the packaging enclosure over a hook or peg. In one embodiment the packaging enclosure conforms to the endoscope so that its two flexible portions may hang over opposite sides of the hook. Alternatively, a hook or aperture may be provided on the packaging enclosure for hanging it over the hook.

Sterile packaging for flexible endoscopes

An apparatus for monitoring the concentration of an oxidative gas or vapor includes a chemical substance which reacts with the oxidative gas or vapor to produce a heat change. A temperature probe is coupled to the chemical substance and adapted to respond to the heat change. The temperature probe can be coupled to the chemical substance by a carrier, and can include a reference temperature probe. Additionally, a method of using the apparatus is described, as well as a sterilization system which utilizes the apparatus.

Monitoring of sterilant apparatus and method for monitoring sterilant

A monitor of the concentration of an oxidative gas or vapor comprises a chemical coupled to a temperature probe, such as by a carrier. Addtionally, the monitor is used in a method of monitoring the concentration of an oxidative gas or vapor and in a sterilization system operated by a user. By utilizing an output signal from the temperature probe to measure the heat produced in an exothermic reaction between the monitored oxidative gas or vapor and the chemical of the monitor, the concentration of the monitored oxidative gas or vapor can be determined. The present invention represents an improvement over the monitors described in the prior art since it is more simplified, and can provide information on the local concentration of an oxidative gas or vapor at various positions within a chamber, and can be operated in size-restricted volumes. Additionally, a method of using the monitor is described, as well as a sterilization system which utilizes the monitor.

Medical instruments incorporating solid lubricants are shown to survive an oxidizing sterilization process if they employ solid lubricants free from disulfide and diselenide compounds such as molybdenum disulfide and the instrument is kept free from such compounds. PTFE, powdered graphite and boron nitride are preferred solid lubricants. Of particular importance are flexible endoscope employing solid lubricants on fiber optic bundles encased in elastomeric coverings.

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Foothill Ranch, CA, United States of America

Debra Timm