Arrow Therapeutics Limited

Virogen Ltd.

Debra Taylor

Malcolm Clive Carter

Richard Kelsey

Lara Wilson

Elisa Henderson

Stan Tyms

Verity Dowdell

Phil Chambers

Dagmar Alber

Kenneth Powell

Albert Stanley Tyms

Philip Chambers

Stanley Tyms

A pharmaceutical composition which comprises a pharmaceutically acceptable carrier or diluent and: (a) an inhibitor of the RSV fusion protein; and (b) a benzodiazepine derivative capable of inhibiting RSV replication is found to be highly active against RSV.

Pharmaceutical composition comprising a benzodiazepine derivative and an inhibitor of the RSV fusion protein

Benzodiazepine derivative of formula (I), and pharmaceutically acceptable salts thereof, are found to be active against RSV Formula (I) Wherein: &#x2014;Rrepresents Calkyl, aryl or heteroaryl; &#x2014;Rrepresents hydrogen or Calkyl; -each Ris the same or different and represents halogen, hydroxy, Calkyl, Calkoxy, Calkylthio Chaloalkyl, Chaloalkoxy, amino, mono(Calkyl)amino, di(Calkyl)amino, nitro, cyano, &#x2014;COR', CONR&#x2032;R&#x2033;, &#x2014;NH&#x2014;CO&#x2014;R&#x2032;, &#x2014;S(O)R&#x2032;, &#x2014;S(O)R&#x2032;, &#x2014;NH&#x2014;S(O)R&#x2032;, &#x2014;S(O)NR&#x2032;R&#x2033; or &#x2014;S(O)NR&#x2032;R&#x2033; wherein each R&#x2032; and R&#x2033; is the same or different and represents hydrogen or Calkyl; -n is from 0 to 3; Rrepresents hydrogen or Calkyl; &#x2014;Rrepresents Calkyl, aryl, heteroaryl, carbocyclyl, heterocyclyl, aryl-(Calkyl)-, heteroaryl-(Calkyl)-, carbocyclyl-(Calkyl)-, heterocyclyl-(Calkyl)-, aryl-C(O)&#x2014;C(O)&#x2014;, heteroaryl-C(O)&#x2014;C(O)&#x2014;, carbocyclyl-C(O)&#x2014;C(O)&#x2014;, heterocyclyl-C(O)&#x2014;C(O)&#x2014; or, &#x2014;XR; &#x2014;X represents &#x2014;CO&#x2014;, &#x2014;S(O)&#x2014; or &#x2014;S(0)&#x2014;; and &#x2014;Rrepresents Calkyl, hydroxy, Calkoxy, Calkylthio, aryl, heteroaryl, carbocyclyl, heterocyclyl, aryl-(Calkyl)-, heteroaryl-(Calkyl)-, carbocyclyl-(Calkyl)-, heterocyclyl-(Calkyl)-, aryl-(Chydroxyalkyl)-, heteroaryl-(Chydroxyalkyl)-, carbocyclyl-(Chydroxyalkyl)-, heterocyclyl-(Chydroxyalkyl)-, aryl-(Calkyl)-O&#x2014;, heteroaryl-(Calkyl)-O&#x2014;, carbocyclyl-(Calkyl)-O&#x2014;, heterocyclyl-(Calkyl)-O&#x2014; or &#x2014;NR&#x2032;R&#x2033; wherein each R&#x2032; and R&#x2033; is the same or different and represents hydrogen, Calkyl, carbocyclyl, heterocyclyl, aryl, heteroaryl, aryl-(Calkyl)-, heteroaryl-(Calkyl)-, carbocyclyl-(Calkyl)- or heterocyclyl-(Calkyl)-. 

Benzodiazepine derivatives and pharmaceutical compositions containing them

Use of certain castanospermine esters in the treatment of diseases caused by flaviviruses, in particular in the treatment of disease caused by the hepatitis C virus (HCV) and compositions containing said esters in combination with adjunctive therapeutic agents.

Antiviral compounds

Benzodiazepine derivative of formula (I), and pharmaceutically acceptable salts thereof, are found to be active against RSV. Formula (I) Wherein: &#x2014;Rrepresents Calkyl, aryl or heteroaryl; &#x2014;Rrepresents hydrogen or Calkyl; &#x2014;each Ris the same or different and represents halogen, hydroxy, Calkyl, Calkoxy, Calkylthio, Chaloalkyl, Chaloalkoxy, amino, mono(Calkyl)amino, di(Calkyl)amino, nitro, cyano, &#x2014;COR', &#x2014;CONR&#x2032;R&#x2033;, &#x2014;NH&#x2014;CO&#x2014;R&#x2032;, &#x2014;S(O)R&#x2032;, &#x2014;S(O)R&#x2032;, &#x2014;NH&#x2014;S(O)R&#x2032;, &#x2014;S(O)NR&#x2032;R&#x2033; or &#x2014;S(O)NR&#x2032;R&#x2033; wherein each R&#x2032; and R&#x2033; is the same or different and represents hydrogen or Calkyl; &#x2014;n is from 0 to 3; Rrepresents hydrogen or Calkyl; &#x2014;Rrepresents Calkyl, aryl, heteroaryl, carbocyclyl, heterocyclyl, aryl-(Calkyl)-, heteroaryl-(Calkyl)-, carbocyclyl-(Calkyl)-, heterocyclyl-(Calkyl)-, aryl-C(O)&#x2014;C(O)&#x2014;, heteroaryl-C(O)&#x2014;C(O)&#x2014;, carbocyclyl-C(O)&#x2014;C(O)&#x2014;, heterocyclyl-C(O)&#x2014;C(O)&#x2014; or, &#x2014;XR; &#x2014;X represents &#x2014;CO&#x2014;, &#x2014;S(O)&#x2014; or &#x2014;S(O)&#x2014;; and &#x2014;Rrepresents Calkyl, hydroxy, Calkoxy, Calkylthio, aryl, heteroaryl, carbocyclyl, heterocyclyl, aryl-(Calkyl)-, heteroaryl-(Calkyl)-, carbocyclyl-(Calkyl)-, heterocyclyl-(Calkyl)-, aryl-(Chydroxyalkyl)-, heteroaryl-(Chydroxyalkyl)-, carbocyclyl-(Chydroxyalkyl)-, heterocyclyl-(Chydroxyalkyl)-, aryl-(Calkyl)-O&#x2014;, heteroaryl-(Calkyl)-O&#x2014;, carbocyclyl-(Calkyl)-O&#x2014;, heterocyclyl-(Calkyl)-O&#x2014; or &#x2014;NR&#x2032;R&#x2033; wherein each R&#x2032; and R&#x2033; is the same or different and represents hydrogen, Calkyl, carbocyclyl, heterocyclyl, aryl, heteroaryl, aryl-(Calkyl)-, heteroaryl-(Calkyl)-, carbocyclyl-(Calkyl)- or heterocyclyl-(Calkyl)-. 

Growing community of inventors

London, United Kingdom

Debra Taylor