Millennium Pharmaceuticals Limited

Other

Millenium Pharmaceuticals, Inc.

Debra L Mazaik

Eric L Elliott

Phuong Nguyen

Raymond D Skwierczynski

Nobel T Truong

Michael J Kaufman

Quentin J McCubbin

Vaithianathan Palaniappan

Csanad M Varga

Abu J Ferdous

Peter Zawaneh

Sonja A Komar-Lay

Patricia Andres

Marianne Langston

Sonja A Komar

Peter N Zawaneh

Quentin J Mccubbin

Jing Teng

Phoung M Nguyen

Anton Peterson

Sarah Bethune

Sonja A Komar Lay

The present invention provides novel compounds useful as proteasome inhibitors. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various diseases.

Boronate ester compounds and pharmaceutical compositions thereof

The present invention is directed to cocrystal forms of ((1S,2S,4R)-4-{4-[(1S)-2,3-dihydro-1H-inden-1-ylamino]-7H-pyrrolo[2,3-d]pyrimidin-7-yl}-2-hydroxcyclopentyl) methyl sulfamate of formula (I). The invention is also directed to methods of making cocrystal forms of ((1S,2S,4R)-4-{4-[(1S)-2,3-dihydro-1H-inden-1-ylamino]-7H-pyrrolo[2,3-d]pyrimidin-7-yl}-2-hydroxycyclopentyl) methyl sulfamate of formula (I). The invention is also directed to the pharmaceutical use of a cocrystal form as an E1 activating enzyme inhibitor, as well as a pharmaceutical composition comprising a cocrystal form. The invention is further directed to a method of treatment comprising administering a cocrystal form of ((1S,2S,4R)-4-{4-[(1S)-2,3-dihydro-1H-inden-1-ylamino]-7H-pyrrolo [2,3-d]pyrimidin-7-yl}-2-hydroxycyclopentyl)methyl sulfamate of formula (I). 

Cocrystal forms of ((1S,2S,4R)-4-{4-[(1S)-2,3-dihydro-1H-inden-1-ylamino]-7H-pyrrolo [2,3-d]pyrimidin-7-yl}-2-hydroxycyclopentyl) methyl sulfamate, formulations and uses thereof

The present disclosure relates to a novel crystalline form of a proteasome inhibitor, and to the processes for the preparation thereof. The novel crystalline form according to the disclosure may be used in the preparation of pharmaceutical compositions for the treatment of cancer.

Crystalline form of a proteasome inhibitor

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Holliston, MA, United States of America

Debra L Mazaik