University of California

Utah State University

Debra Arliene Feakes

Marion Frederick Hawthorne

Kenneth John Shelly

Karen W Morse

Mallaiah Mittakanti

Mohammad-Reza M-d Charandabi

Boron neutron capture therapy can utilize X.sub.y B.sub.20 H.sub.17 L where X is an alkali metal, y is 1 to 4, and L is a two electron donor such as NH.sub.3, and Na.sub.2 B.sub.10 H.sub.9 NCO, among others. These borane salts may be used free or encapsulated in liposomes. Liposomes may have embedded within their bilayers carboranes to increase the amount of delivered .sup.10 B and/or to increase the tumor specificity of the liposome.

Liposome compositions for boron neutron capture therapy and methods

Compositions for boron neutron capture therapy and methods thereof

Alkylcarbamoylborane cyclic dimers are synthesized through reactions of alkylcarbamoylborane adducts of amines. The inventive dimers have utility as reactants in the direct synthesis of alkylcarbamoylborane adducts of primary and secondary amines. Alkylcarbamoylborane adducts of primary and secondary amines and certain of the inventive dimers have biological activity as anti-tumor, hypocholesteremic, and anti-inflammatory agents. The cyclic dimers of this invention have the formula [BHRC(O)NHR'].sub.2, examples of which include:

Alkylcarbamoylborane cyclic dimers

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Los Angeles, CA, United States of America

Debra Arliene Feakes